Ischemia-reperfusion injury and the risk of hepatocellular carcinoma recurrence after deceased donor liver transplantation

This study aimed to evaluate the effects of ischemia-reperfusion injury (IRI) on the risk of hepatocellular carcinoma (HCC) recurrence after liver transplantation. Data of 195 patients were retrospectively analysed. Post-reperfusion aspartate (AST), alanine transaminase, and lactate dehydrogenase (L...

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Bibliographic Details
Published in:Scientific reports 2018-06, Vol.8 (1), p.8935-13, Article 8935
Main Authors: Grąt, Michał, Krawczyk, Marek, Wronka, Karolina M., Stypułkowski, Jan, Lewandowski, Zbigniew, Wasilewicz, Michał, Krawczyk, Piotr, Grąt, Karolina, Patkowski, Waldemar, Zieniewicz, Krzysztof
Format: Article
Language:English
Subjects:
692/4020/4021/1607/1604
692/4020/4021/1607/1610/4029
692/4028/546
692/499
Alanine
Alanine transaminase
Hepatocellular carcinoma
Humanities and Social Sciences
Ischemia
L-Lactate dehydrogenase
Lactic acid
Liver cancer
Liver transplantation
Liver transplants
Microvasculature
multidisciplinary
Reperfusion
Risk factors
Science
Science (multidisciplinary)
Transaminase
Tumors
α-Fetoprotein
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Summary:This study aimed to evaluate the effects of ischemia-reperfusion injury (IRI) on the risk of hepatocellular carcinoma (HCC) recurrence after liver transplantation. Data of 195 patients were retrospectively analysed. Post-reperfusion aspartate (AST), alanine transaminase, and lactate dehydrogenase (LDH) levels were the primary measures of IRI. Tumour recurrence was the primary endpoint. Post-reperfusion AST was a continuous risk factor for tumour recurrence in patients within Milan criteria (p = 0.035), with an optimal cut-off of 1896 U/L. Recurrence-free survival of patients within Milan criteria and post-reperfusion AST of
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-27319-y