Visual Loss Induced by Adalimumab Used for Plaque Psoriasis

A 61-year-old Caucasian male with severe plaque psoriasis without joint involvement was initiated on adalimumab therapy. Shortly thereafter he presented to the emergency room with acute loss of vision in the right eye. A comprehensive systemic workup was instituted which included magnetic resonance...

Full description

Saved in:
Bibliographic Details
Published in:Case reports in dermatology 2017-01, Vol.9 (1), p.60-64
Main Authors: Saffra, Norman, Astafurov, Konstantin
Format: Article
Language:English
Subjects:
Adalimumab
Arthritis
Case reports
Defects
Demyelination
Field study
Gangrene
Guillain-Barre syndrome
Immunotherapy
Loss of vision
Monoclonal antibodies
Multiple sclerosis
NMR
Nuclear magnetic resonance
Optic neuritis
Psoriasis
Single Case
TNF inhibitors
Tumor necrosis factor-TNF
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A 61-year-old Caucasian male with severe plaque psoriasis without joint involvement was initiated on adalimumab therapy. Shortly thereafter he presented to the emergency room with acute loss of vision in the right eye. A comprehensive systemic workup was instituted which included magnetic resonance imaging (MRI) with and without gadolinium of the brain and orbits. MRI revealed findings that were consistent with CNS demyelination and retrobulbar optic neuritis. Immediate cessation of adalimumab was instituted without any other systemic therapy. Complete return of vision occurred within 6 weeks. No additional psoriatic or neurologic treatment was instituted, and the patient has remained stable now for 14 months.
ISSN:1662-6567
1662-6567
DOI:10.1159/000461572