Exosomes in the tumor microenvironment of cholangiocarcinoma: current status and future perspectives

Cholangiocarcinoma (CCA) refers to an aggressive malignancy with a high fatality rate and poor prognosis. Globally, the morbidity of CCA is increasing for the past few decades, which has progressed into a disease that gravely endangers human health. Exosomes belong to a class of extracellular vesicl...

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Bibliographic Details
Published in:Journal of translational medicine 2022-03, Vol.20 (1), p.117-117, Article 117
Main Authors: Zhao, Kai, Li, Xiangyu, Shi, Yuanxin, Lu, Yun, Qiu, Peng, Deng, Zhengdong, Yao, Wei, Wang, Jianming
Format: Article
Language:English
Subjects:
Biomarker
Cholangiocarcinoma
Exosomes
Liquid biopsy
Review
Targeted therapy
Tumor microenvironment
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Summary:Cholangiocarcinoma (CCA) refers to an aggressive malignancy with a high fatality rate and poor prognosis. Globally, the morbidity of CCA is increasing for the past few decades, which has progressed into a disease that gravely endangers human health. Exosomes belong to a class of extracellular vesicles (EVs) with diameters ranging from 40 to 150 nm that can be discharged by all living cells. As communication messengers of the intercellular network, exosomes carry a diverse range of cargoes such as proteins, nucleic acids, lipids, and metabolic substances, which are capable of conveying biological information across different cell types to mediate various physiological activities or pathological changes. Increasing studies have demonstrated that exosomes in the tumor microenvironment participate in regulating tumorigenesis and progression via multiple approaches in the tumor microenvironment. Here, we reviewed the current research progress of exosomes in the context of cancer and particularly highlighted their functions in modulating the development of CCA. Furthermore, the potential values of exosomes as diagnostic and therapeutic targets in CCA were overviewed as well.
ISSN:1479-5876
1479-5876
DOI:10.1186/s12967-022-03294-x