Role of Small Molecule Targeted Compounds in Cancer: Progress, Opportunities, and Challenges

Research on molecular targeted therapy of tumors is booming, and novel targeted therapy drugs are constantly emerging. Small molecule targeted compounds, novel targeted therapy drugs, can be administered orally as tablets among other methods, and do not draw upon genes, causing no immune response. I...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in cell and developmental biology 2021-09, Vol.9, p.694363-694363
Main Authors: Sun, Guoqiang, Rong, Dawei, Li, Zhouxiao, Sun, Guangshun, Wu, Fan, Li, Xiao, Cao, Hongyong, Cheng, Ye, Tang, Weiwei, Sun, Yangbai
Format: Article
Language:English
Subjects:
carcinoma
Cell and Developmental Biology
drug resistance
small molecular compounds
target
therapy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Research on molecular targeted therapy of tumors is booming, and novel targeted therapy drugs are constantly emerging. Small molecule targeted compounds, novel targeted therapy drugs, can be administered orally as tablets among other methods, and do not draw upon genes, causing no immune response. It is easily structurally modified to make it more applicable to clinical needs, and convenient to promote due to low cost. It refers to a hotspot in the research of tumor molecular targeted therapy. In the present study, we review the current Food and Drug Administration (FDA)-approved use of small molecule targeted compounds in tumors, summarize the clinical drug resistance problems and mechanisms facing the use of small molecule targeted compounds, and predict the future directions of the evolving field.
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2021.694363