Cannabidiol in the acute phase of febrile infection‐related epilepsy syndrome (FIRES)

Febrile infection‐related epilepsy syndrome (FIRES) is a prolonged refractory status epilepticus (SE) that develops among healthy individuals after a febrile infection. FIRES treatment is challenging due to its poor response to antiseizure medications (ASMs) and anesthetic drugs. The use of cannabid...

Full description

Saved in:
Bibliographic Details
Published in:Epilepsia open 2023-06, Vol.8 (2), p.685-691
Main Authors: Fetta, Anna, Crotti, Elisa, Campostrini, Elena, Bergonzini, Luca, Cesaroni, Carlo Alberto, Conti, Francesca, Di Pisa, Veronica, Gentile, Valentina, Mondardini, Maria Cristina, Vezzoli, Cesare, Giordano, Lucio, Cordelli, Duccio Maria
Format: Article
Language:English
Subjects:
Cannabidiol
CBD
Convulsions & seizures
cytokine
Drug dosages
Electroencephalography
Epilepsy
Family medical history
Fever
Infections
Intensive care
Leukocytes
Magnetic resonance imaging
neuroinflammation
Pediatrics
Rehabilitation
Short
Short s
status epilepticus
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Febrile infection‐related epilepsy syndrome (FIRES) is a prolonged refractory status epilepticus (SE) that develops among healthy individuals after a febrile infection. FIRES treatment is challenging due to its poor response to antiseizure medications (ASMs) and anesthetic drugs. The use of cannabidiol (CBD) as an adjunctive treatment has been suggested, albeit data about its role in the acute phase is lacking. This report describes the use of purified CBD in the acute phase of two pediatric cases of FIRES and their long‐term outcome. Both children were treated with several ASMs, immunomodulators, anesthetics, and nonpharmacological treatment (ketogenic diet). CBD was administered, as an adjunctive treatment, through nasogastric tube about 30 days after onset. SE resolved within 3 days of reaching the target dose and both were seizure‐free for 1 year after. Although it is difficult to define the extent to which each previous therapy contributed to recovery, in both cases CBD therapy was a turning point, reinforcing its potential role as add‐on treatment in the acute phase of FIRES.
ISSN:2470-9239
2470-9239
DOI:10.1002/epi4.12740