Association of High Vitamin D Status with Low Circulating Thyroid-Stimulating Hormone Independent of Thyroid Hormone Levels in Middle-Aged and Elderly Males

Background. A recent study has reported that high circulating 25-hydroxyvitamin D [25(OH)D] is associated with low circulating thyroid-stimulating hormone (TSH) levels, but only in younger individuals. The goal of the present study was to explore the relationship between vitamin D status and circula...

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Published in:International Journal of Endocrinology 2014-01, Vol.2014 (2014), p.342-347-138
Main Authors: Li, Yanyun, Shi, Yun, Zheng, Shuai, Tang, Wei, Duan, Yu, Huang, Xiaoping, He, Wei, Yang, Tao, Mao, Jia, Gao, Yuan, Fu, Qi, Zhu, Zhenxin, Cao, Mengdie, Sun, Min, Wang, Zhixiao, Zhang, Qingqing, Yang, Fan
Format: Article
Language:English
Subjects:
Aged
Alfacalcidol
Body mass index
Calcifediol
Endocrinology
Hyperthyroidism
Immunoassay
Laboratories
Males
Middle age
Middle aged persons
Physiological aspects
Regression analysis
Thyroid diseases
Thyrotropin
Vitamin D
Vitamin deficiency
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Summary:Background. A recent study has reported that high circulating 25-hydroxyvitamin D [25(OH)D] is associated with low circulating thyroid-stimulating hormone (TSH) levels, but only in younger individuals. The goal of the present study was to explore the relationship between vitamin D status and circulating TSH levels with thyroid autoimmunity and thyroid hormone levels taken into consideration in a population-based health survey of middle-aged and elderly individuals. Methods. A total of 1,424 Chinese adults, aged 41–78 years, were enrolled in this cross-sectional study. Serum levels of 25(OH)D, TSH, thyroid hormones, and thyroid autoantibodies were measured. Results. The prevalence of vitamin D insufficiency was 94.29% in males and 97.22% in females, and the prevalence of vitamin D deficiency was 55.61% in males and 69.64% in females. Vitamin D status was not associated with positive thyroid autoantibodies after controlling for age, gender, body mass index, and smoking status. Higher 25(OH)D levels were associated with lower TSH levels after controlling for age, FT4 and FT3 levels, thyroid volume, the presence of thyroid nodule(s), and smoking status in males. Conclusion. High vitamin D status in middle-aged and elderly males was associated with low circulating TSH levels independent of thyroid hormone levels.
ISSN:1687-8337
1687-8345
DOI:10.1155/2014/631819