The Overexpression and Clinical Significance of AP1S1 in Breast Cancer

To explore the mechanism of AP1S1 in breast cancer. In different datasets, we found that AP1S1 is more highly expressed in breast tumors, which was furthermore verified in our local cohort.Immune infiltration analysis showed that AP1S1 was related to a variety of immune cells. The higher AP1S1 expre...

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Bibliographic Details
Published in:Cancer management and research 2022-01, Vol.14, p.1475-1492
Main Authors: Zheng, Danni, Fu, Weida, Jin, Lingli, Jiang, Xiaofang, Jiang, Wenjie, Guan, Yaoyao, Hao, Rutian
Format: Article
Language:English
Subjects:
ap1s1
Breast cancer
Estrogen
Gene expression
Genes
immune infiltration
Metastasis
oncogene
Original Research
prognosis
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Summary:To explore the mechanism of AP1S1 in breast cancer. In different datasets, we found that AP1S1 is more highly expressed in breast tumors, which was furthermore verified in our local cohort.Immune infiltration analysis showed that AP1S1 was related to a variety of immune cells. The higher AP1S1 expression was negatively correlated with a variety of immune infiltrating cells, suggesting that AP1S1 may affect cellular immunity.Clinical analysis showed that patients with higher AP1S1 expression had higher estrogen receptor gene expression and were more prone to distant metastasis and lymph node metastasis.The overall survival rate, disease-specific survival rate, and progression-free interval time were worse in the group with higher AP1S1 expression. AP1S1 may be a potential oncogene of breast cancer, and overexpression is related to the poor prognosis of breast cancer.Therefore, a nomogram was constructed, along with correlated gene analysis and functional analysis to further explore the carcinogenic mechanism, practical clinical issues, and value of AP1S1. AP1S1 is a potential oncogene of breast cancer.
ISSN:1179-1322
1179-1322
DOI:10.2147/CMAR.S346519