Roles of Macrophages and Endothelial Cells and Their Crosstalk in Acute Lung Injury

Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), present life-threatening conditions characterized by inflammation and endothelial injury, leading to increased vascular permeability and lung edema. Key players in the pathogenesis and resolution of ALI are macr...

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Bibliographic Details
Published in:Biomedicines 2024-03, Vol.12 (3), p.632
Main Authors: Osorio-Valencia, Sara, Zhou, Bisheng
Format: Article
Language:English
Subjects:
acute lung injury
Acute respiratory distress syndrome
Antigen presentation
Cell growth
Chemokines
Cytokines
Edema
Endothelial cells
Endothelium
Epidermal growth factor
Fibroblasts
Health aspects
Immunomodulation
Inflammation
lung injury and repair
Lungs
Macrophages
Pathogenesis
Pathogens
Permeability
Proteins
R&D
Research & development
Respiratory distress syndrome
Review
Roles
Smooth muscle
Therapeutic applications
Tumor necrosis factor-TNF
vascular permeability
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Summary:Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), present life-threatening conditions characterized by inflammation and endothelial injury, leading to increased vascular permeability and lung edema. Key players in the pathogenesis and resolution of ALI are macrophages (Mφs) and endothelial cells (ECs). The crosstalk between these two cell types has emerged as a significant focus for potential therapeutic interventions in ALI. This review provides a brief overview of the roles of Mφs and ECs and their interplay in ALI/ARDS. Moreover, it highlights the significance of investigating perivascular macrophages (PVMs) and immunomodulatory endothelial cells (IMECs) as crucial participants in the Mφ-EC crosstalk. This sheds light on the pathogenesis of ALI and paves the way for innovative treatment approaches.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines12030632