Globally elevated excitation-inhibition ratio in children with autism spectrum disorder and below-average intelligence

Altered neuronal excitation-inhibition (E-I) balance is strongly implicated in ASD. However, it is not known whether the direction and degree of changes in the E-I ratio in individuals with ASD correlates with intellectual disability often associated with this developmental disorder. The spectral sl...

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Bibliographic Details
Published in:Molecular autism 2022-05, Vol.13 (1), p.20-20, Article 20
Main Authors: Manyukhina, Viktoriya O, Prokofyev, Andrey O, Galuta, Ilia A, Goiaeva, Dzerassa E, Obukhova, Tatiana S, Schneiderman, Justin F, Altukhov, Dmitrii I, Stroganova, Tatiana A, Orekhova, Elena V
Format: Article
Language:English
Subjects:
1/f power law
Age
Animal cognition
Autism
Autism Spectrum Disorder
Autism spectrum disorders (ASDs)
Autistic children
Biomarkers
Brain research
Caregivers
Child
Children & youth
Cognition - physiology
Cognitive ability
eeg
excitability
Excitation-inhibition balance
excitation/inhibition
excitatory/inhibitory balance
f power law
Genetics & Heredity
Humans
Intellectual disabilities
Intellectual Disability
Intelligence
interneurons
Magnetic resonance imaging
Magnetoencephalography
Male
meg
mouse
Neurosciences
Neurosciences & Neurology
Neurovetenskaper
Power spectrum
reliability
resting-state
Standard scores
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Summary:Altered neuronal excitation-inhibition (E-I) balance is strongly implicated in ASD. However, it is not known whether the direction and degree of changes in the E-I ratio in individuals with ASD correlates with intellectual disability often associated with this developmental disorder. The spectral slope of the aperiodic 1/f activity reflects the E-I balance at the scale of large neuronal populations and may uncover its putative alternations in individuals with ASD with and without intellectual disability. Herein, we used magnetoencephalography (MEG) to test whether the 1/f slope would differentiate ASD children with average and below-average (
ISSN:2040-2392
2040-2392
DOI:10.1186/s13229-022-00498-2