Real Life Experience Regarding Clinical Characteristics and Treatment Outcome in Non-Cutaneous Peripheral T Cell Lymphomas: A Multicenter Study of Turkish Hematology Research and Education Group (Threg)

• Published in: Turkish journal of haematology 2022-01, Vol.39 (3), p.170-177
• Main Authors: Kayıkçı, Ömür, Mehtap, Özgür, Sarı, İsmail, Demirkan, Fatih, Beyan, Cengiz, Çetin, Güven, Vural, Filiz, Yılmaz, Mehmet, Öztürk, Erman, Akpınar, Seval, Eser, Bülent, Gündüz, Mehmet, Büyükaşık, Yahya, Payzın, Bahriye, Yıldırım, Rahşan, Doğu, Mehmet Hilmi, Özkan, Atilla, Kelkitli, Engin, Tekgündüz, Emre
• Format: Article
• Language: English
• Subjects: autologous stem cell transplantation; Lymphoma; lymphomas; non-hodgkin lymphoma; t-cell lymphomas; Transplants & implants
• ISSN: 1300-7777; 1308-5263
• DOI: 10.4274/tjh.galenos.2022.2022.0052

Peripheral T-NK-cell lymphomas (PTCL) are uncommon, quite heterogeneous group of disorders, and representing only 10-15% of all non-Hodgkin lymphomas (NHL). Although both molecular and clinical studies have been increased in recent years, we have still little knowledge regarding the real-life practice on PTCLs. In this study, we aimed to investigate the clinical characteristics and treatment outcomes in a large population-based cohort of patients presenting with systemic non-cutaneous PTCL patients. We conducted a multicenter retrospective analysis of 190 patients consecutively diagnosed and treated with non-cutaneous PTCLs between 2008 and 2016. Considering all first-line treatment combinations, the overall response rate (ORR) was 65.9% with 49.4% complete remission (CR) (n=81) and 16.5% partial response (PR) (n=27). The 5-year OS and EFS rates were significantly different between the transplant and non-transplant groups (p