Impact of bacterial infections prior to liver transplantation on post-transplant outcomes in patients with cirrhosis

Bacterial infections are frequent in patients with cirrhosis and increase the risk of death and drop-out from liver transplant (LT) waiting list. In patients with bacterial infections, LT is frequently delayed because of the fear of poor outcomes. We evaluated the impact of pre-LT infections on post...

Full description

Saved in:
Bibliographic Details
Published in:JHEP reports 2023-09, Vol.5 (9), p.100808, Article 100808
Main Authors: Incicco, Simone, Tonon, Marta, Zeni, Nicola, Gambino, Carmine, Gagliardi, Roberta, Calvino, Valeria, Barone, Anna, Zilio, Gianluca, Feltracco, Paolo, Burra, Patrizia, Cillo, Umberto, Angeli, Paolo, Piano, Salvatore
Format: Article
Language:English
Subjects:
Acute-on-chronic liver failure
Liver cirrhosis
Liver transplantation
Prioritisation
Sepsis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Bacterial infections are frequent in patients with cirrhosis and increase the risk of death and drop-out from liver transplant (LT) waiting list. In patients with bacterial infections, LT is frequently delayed because of the fear of poor outcomes. We evaluated the impact of pre-LT infections on post-LT complications and survival. From 2012 to 2018, consecutive patients transplanted at the Hospital of Padua were identified and classified in two groups: patients surviving an episode of bacterial infection within 3 months before LT (study group) and patients without infections before LT (control group). Post-LT outcomes (complications, new infections, survival) were collected. A total of 466 LT recipients were identified (study group n = 108; control group n = 358). After LT, the study group had a higher incidence of new bacterial (57% vs. 20%, p
ISSN:2589-5559
2589-5559
DOI:10.1016/j.jhepr.2023.100808