The effect of surface treatment on the brain delivery of curcumin nanosuspension: in vitro and in vivo studies

Curcumin, a bioactive component with multiple characteristics, has been shown to have many therapeutic effects. However, there are several limitations regarding the use of curcumin such as instability, low solubility, poor bioavailability, and rapid elimination. Different approaches have been used t...

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Bibliographic Details
Published in:International journal of nanomedicine 2019-01, Vol.14, p.5477-5490
Main Authors: Dibaei, Maryam, Rouini, Mohammad-Reza, Sheikholeslami, Behjat, Gholami, Mahdi, Dinarvand, Rassoul
Format: Article
Language:English
Subjects:
Adsorption
Alzheimer's disease
Apolipoproteins
Bioavailability
biodistribution
Brain
Brain research
Chromatography
Curcumin
Drug delivery systems
Fluorescence
Glycols (Class of compounds)
Health aspects
High performance liquid chromatography
Liquid chromatography
Liver
Nanocrystals
Nanoparticles
nanosuspensions
Novels
Original Research
Particle size
Pharmaceutical sciences
pharmacokinetics
Pharmacy
Polyethylene glycol
Polyols
Povidone
Surface active agents
Surfactants
TPGS
Tween
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Summary:Curcumin, a bioactive component with multiple characteristics, has been shown to have many therapeutic effects. However, there are several limitations regarding the use of curcumin such as instability, low solubility, poor bioavailability, and rapid elimination. Different approaches have been used to solve these problems. In this study, surface-modified nanosuspension (NS) is investigated as a novel brain delivery system. Two different methods were used for the preparation of nanosuspensions with two different stabilizers. The surface of the nanosuspensions was coated with D-α-tocopheryl polyethylene glycol 1,000 succinate (TPGS) and Tween 80 using physical adsorption. Curcumin NSs were prepared using two different top-down techniques by high-pressure homogenizer and probe sonicator. A validated sensitive and selective high-performance liquid chromatography method using fluorescence detection was used for the determination and quantification of curcumin. Pharmacokinetics and biodistribution of curcumin NSs and solutions after intravenous administration in rats were studied. Higher levels of curcumin in the brain were detected when Tween 80-coated NS was used compared with the curcumin solution and TPGS coated NS (TPGS-NS) ( -value
ISSN:1178-2013
1176-9114
1178-2013
DOI:10.2147/IJN.S199624