The expression of substance P and calcitonin gene-related peptide is associated with the severity of tendon degeneration in lateral epicondylitis

In this study, we investigated whether substance P (SP) or calcitonin gene-related peptide (CGRP) expression is associated with tendon degeneration in patients with lateral epicondylitis. Twenty-nine patients who underwent surgical treatment for lateral epicondylitis were enrolled in the final analy...

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Bibliographic Details
Published in:BMC musculoskeletal disorders 2021-02, Vol.22 (1), p.210-10, Article 210
Main Authors: Han, Soo-Hong, Kim, Hyung Kyung, Jang, Yoon, Lee, Hyeon Hae, Rhie, Jeongbae, Han, Donghun, Oh, Jongbeom, Lee, Soonchul
Format: Article
Language:English
Subjects:
Biopsy
Calcitonin
Calcitonin Gene-Related Peptide
Complications and side effects
Connective tissue diseases
Degeneration
Degeneration (Pathology)
Elbow
Extracellular matrix
Gene expression
Genetic aspects
Health aspects
Humans
Immunoreactivity
Lateral epicondylitis
Multivariate analysis
Musculoskeletal diseases
Pain
Patients
Peptides
Protein expression
Proteins
Risk factors
Substance P
Surgeons
Surgery
Tendinopathy
Tendon degeneration
Tendons
Tendons - surgery
Tennis elbow
Tennis Elbow - surgery
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Summary:In this study, we investigated whether substance P (SP) or calcitonin gene-related peptide (CGRP) expression is associated with tendon degeneration in patients with lateral epicondylitis. Twenty-nine patients who underwent surgical treatment for lateral epicondylitis were enrolled in the final analyses. Extensor carpi radialis brevis tendon origins were harvested for histological analysis. SP and CGRP immunostaining were negative in healthy tendons but positive in degenerative tendons; moreover, their immunoreactivity increased with degeneration severity. Univariate analysis indicated that variables such as the preoperative visual analog scale (VAS) score or SP or CGRP expression levels were significantly associated with the Movin score. However, multivariate analysis revealed that only higher SP and/or CGRP signals were associated with higher Movin scores. Elevations in SP or CGRP expression were also linked with significantly severe preoperative VAS scores. We demonstrated that tendon degeneration severity is associated with increased SP and CGRP expression in the biopsy samples of lateral epicondylitis.
ISSN:1471-2474
1471-2474
DOI:10.1186/s12891-021-04067-1