Treatment failure in a typhoid patient infected with nalidixic acid resistant S. enterica serovar Typhi with reduced susceptibility to ciprofloxacin: a case report from Cameroon

Fluoroquinolones or third generation cephalosporins are the drugs of choice for the treatment of typhoid fever. Treatment failure with fluoroquinolones has been reported in Asia and Europe. We report a case of ciprofloxacin treatment failure in typhoid fever in Cameroon. A 29-year-old female patient...

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Bibliographic Details
Published in:BMC infectious diseases 2005-06, Vol.5 (1), p.49-49, Article 49
Main Authors: Nkemngu, Njinkeng J, Asonganyi, Etienne D N, Njunda, Anna L
Format: Article
Language:English
Subjects:
Adult
Anti-Bacterial Agents - therapeutic use
Cameroon
Case Report
Ceftriaxone - therapeutic use
Ciprofloxacin - pharmacology
Ciprofloxacin - therapeutic use
Drug Resistance, Multiple, Bacterial
Female
Humans
Microbial Sensitivity Tests
Nalidixic Acid - pharmacology
Salmonella enterica
Salmonella typhi - drug effects
Treatment Failure
Typhoid Fever - drug therapy
Typhoid Fever - microbiology
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Summary:Fluoroquinolones or third generation cephalosporins are the drugs of choice for the treatment of typhoid fever. Treatment failure with fluoroquinolones has been reported in Asia and Europe. We report a case of ciprofloxacin treatment failure in typhoid fever in Cameroon. A 29-year-old female patient with suspected typhoid fever from Kumba, Cameroon, yielded growth of Salmonella enterica serovar Typhi in blood culture. The isolate was resistant to nalidixic acid but sensitive to ciprofloxacin by disc diffusion test. However, the patient did not respond to treatment with ciprofloxacin, although the isolate was apparently susceptible to ciprofloxacin. Treatment failure with ciprofloxacin in our case indicates the presence of nalidixic acid resistant S. enterica serovar Typhi (NARST) with reduced susceptibility to ciprofloxacin in Cameroon (Central Africa).
ISSN:1471-2334
1471-2334
DOI:10.1186/1471-2334-5-49