Cardiovascular Prevention of Cognitive Decline

Midlife cardiovascular risk factors, including diabetes, hypertension, dyslipemia, and an unhealthy lifestyle, have been linked to subsequent incidence, delay of onset, and progression rate of Alzheimer disease and vascular dementia. Conversely, optimal treatment of cardiovascular risk factors preve...

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Bibliographic Details
Published in:Cardiology Research and Practice 2011-01, Vol.2011 (2011), p.215-221-026
Main Authors: Monsuez, Jean-Jacques, Rivera, Sofia, Gesquière-Dando, Aude
Format: Article
Language:English
Subjects:
Cardiovascular system
Cognition disorders
Prevention
Review
Risk factors
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Summary:Midlife cardiovascular risk factors, including diabetes, hypertension, dyslipemia, and an unhealthy lifestyle, have been linked to subsequent incidence, delay of onset, and progression rate of Alzheimer disease and vascular dementia. Conversely, optimal treatment of cardiovascular risk factors prevents and slows down age-related cognitive disorders. The impact of antihypertensive therapy on cognitive outcome in patients with hypertension was assessed in large trials which demonstrated a reduction in progression of MRI white matter hyperintensities, in cognitive decline and in incidence of dementia. Large-scale database correlated statin use and reduction in the incidence of dementia, mainly in patients with documented atherosclerosis, but clinical trials failed to reach similar conclusions. Whether a multitargeted intervention would substantially improve protection, quality of life, and reduce medical cost expenditures in patients with lower risk profile has not been ascertained. This would require appropriately designed trials targeting large populations and focusing on cognitive decline as a primary outcome endpoint.
ISSN:2090-0597
2090-8016
2090-0597
DOI:10.4061/2011/250970