Metabolite profiling and nephroprotective potential of Glycyrrhiza glabra L. roots against cisplatin-induced nephrotoxicity in vitro and in vivo

The present study was conducted to investigate the phytochemical analysis and demonstrate the nephroprotective potential of root extract of L. against cisplatin (CP) -induced nephrotoxicity and The HPTLC analysis and UPLC-MS were carried out for standardizing and metabolite profiling of methanolic e...

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Bibliographic Details
Published in:Iranian journal of basic medical sciences 2022-11, Vol.25 (11), p.1286-1298
Main Authors: Basist, Parakh, Zahiruddin, Sultan, Khan, Mohammad Umar, Gautam, Gaurav, Jan, Bisma, Khan, Mohammad Ahmed, Parveen, Rabea, Ahmad, Sayeed
Format: Article
Language:English
Subjects:
Apoptosis
Chemotherapy
cisplatin
Drug dosages
Education
Electrolytes
Enzymes
Food
glycyrrhizin
glycyrrihza glabra
Herbal medicine
kidney disorder
Laboratories
Medicine
Natural products
nephroprotective
nephrotoxicity
Original
Oxidation
Oxidative stress
Pharmaceutical sciences
Pharmacology
Phytochemicals
Toxicity
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Summary:The present study was conducted to investigate the phytochemical analysis and demonstrate the nephroprotective potential of root extract of L. against cisplatin (CP) -induced nephrotoxicity and The HPTLC analysis and UPLC-MS were carried out for standardizing and metabolite profiling of methanolic extract of roots of (GGE). Further, studies were conducted in human embryonic kidney (HEK)-293 cells to evaluate the cytotoxicity and anti-oxidant potential of GGE with CP as a toxicant and ascorbic acid as standard. Also, nephroprotective potential at doses of 31.5, 63, and 126 mg/kg/day on CP (6 mg/kg, bw, IP) induced nephrotoxicity was evaluated on rodents. Phytochemical analysis by HPTLC and UPLC-MS revealed the presence of glycyrrhizin, glabridin, and liquiritin along with other bioactive constituents. The in vitro assay of GGE showed significant (
ISSN:2008-3866
2008-3874
DOI:10.22038/IJBMS.2022.65478.14404