Sequential Oxygenation Index and Organ Dysfunction Assessment within the First 3 Days of Mechanical Ventilation Predict the Outcome of Adult Patients with Severe Acute Respiratory Failure

To determine early predictors of outcomes of adult patients with severe acute respiratory failure. Method. 100 consecutive adult patients with severe acute respiratory failure were evaluated in this retrospective study. Data including comorbidities, Sequential Organ Failure Assessment (SOFA) score,...

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Bibliographic Details
Published in:TheScientificWorld 2013-01, Vol.2013 (2013), p.1-10
Main Authors: Fang, Wen-Feng, Wang, Chin-Chou, Chou, Po-An, Chen, Yu-Mu, Hung, Heui-Ling, Lai, Ting-Yu, Kao, Hsu-Ching, Lin, Meng-Chih
Format: Article
Language:English
Subjects:
Acute respiratory distress syndrome
Adult
Aged
Aged, 80 and over
APACHE
Artificial respiration
Care and treatment
Clinical Study
Evaluation
Failure
Fatalities
Female
Hospital Mortality
Humans
Intensive Care Units
Kaplan-Meier Estimate
Male
Middle Aged
Mortality
Multivariate Analysis
Organ Dysfunction Scores
Oxygen - metabolism
Oxygenation
Patient outcomes
Predictive Value of Tests
Rank tests
Respiration, Artificial - utilization
Respiratory Distress Syndrome, Adult - metabolism
Respiratory Distress Syndrome, Adult - pathology
Respiratory failure
Retrospective Studies
ROC Curve
Time Factors
Treatment Outcome
Ventilation
Ventilator Weaning - methods
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Summary:To determine early predictors of outcomes of adult patients with severe acute respiratory failure. Method. 100 consecutive adult patients with severe acute respiratory failure were evaluated in this retrospective study. Data including comorbidities, Sequential Organ Failure Assessment (SOFA) score, Acute Physiological Assessment and Chronic Health Evaluation II (APACHE II) score, PaO2, FiO2, PaO2/FiO2, PEEP, mean airway pressure (mPaw), and oxygenation index (OI) on the 1st and the 3rd day of mechanical ventilation, and change in OI within 3 days were recorded. Primary outcome was hospital mortality; secondary outcome measure was ventilator weaning failure. Results. 38 out of 100 (38%) patients died within the study period. 48 patients (48%) failed to wean from ventilator. Multivariate analysis showed day 3 OI (P=0.004) and SOFA (P=0.02) score were independent predictors of hospital mortality. Preexisting cerebrovascular accident (CVA) (P=0.002) was the predictor of weaning failure. Results from Kaplan-Meier method demonstrated that higher day 3 OI was associated with shorter survival time (log-Rank test, P
ISSN:2356-6140
1537-744X
1537-744X
DOI:10.1155/2013/413216