Biomechanical Particularities in the Therapy of the Rheumatic Knee

• Published in: Applied sciences 2020-12, Vol.10 (23), p.8600
• Main Authors: Biehl, Christoph, Heinrich, Martin, Biehl, Lotta, Knapp, Gero, Heiss, Christian, Thormann, Ulrich
• Format: Article
• Language: English
• Subjects: Arthritis; Atrophy; Biomechanics; Biomedical materials; Cartilage; Cell adhesion & migration; Chronic illnesses; Dendritic cells; Experimental research; Extremities; Fibroblasts; Gene expression; Inflammation; Joint diseases; Joints (anatomy); Kinematics; Knee; knee surgery; Ligaments; MicroRNAs; Neutrophils; Osteoarthritis; Oxidative stress; Pain; Patients; Remission; Rheumatoid arthritis; rheumatoid arthritis synovial fibroblast (RASF); sarcopenia; Tendons; Visual fields; Vitamin deficiency
• ISSN: 2076-3417; 2076-3417
• DOI: 10.3390/app10238600

In rheumatoid arthritis, the joints of the lower extremities are almost always affected. This is most conspicuous in the knee joint. In rheumatics, inflammatory osteoarthritis manifests itself comparably earlier than in patients with osteoarthritis. The focus of attention was primarily on the synovia with its destruction process and secondary changes. Now, driven by experimental research, dendritic cells and fibroblasts and molecular features are moving into the clinician’s field of vision. Even in joints that appear to be in remission with no swelling or pain, the activity of these cells leads to changes in the capsule-ligaments. The complex deformities and instabilities caused by this, in conjunction with atrophy of the inter-articular musculature, have an impact on the activities of daily life (ADL). If these biomechanical aspects of the knee joint are not taken into account early on in therapy, the frequency of primary and secondary surgical treatment increases. The timely recognition of biomechanical pathologies and consistent treatment can contribute to improving the patient situation in addition to adequate medication therapy.