DNA-Functionalized Nanoparticles for Targeted Biosensing and Biological Applications

• Published in: ACS omega 2020-12, Vol.5 (48), p.30767-30774
• Main Authors: Singh, Udisha, Morya, Vinod, Rajwar, Anjali, Chandrasekaran, Arun Richard, Datta, Bhaskar, Ghoroi, Chinmay, Bhatia, Dhiraj
• Format: Article
• Language: English
• Subjects: Mini-Review
• ISSN: 2470-1343; 2470-1343
• DOI: 10.1021/acsomega.0c03656

Nanoscale systems have increasingly been used in biomedical applications, enhancing the demand for the development of biomolecule-functionalized nanoparticles for targeted applications. Such designer nanosystems hold great prospective to refine disease diagnosis and treatment. To completely investigate their potential for bioapplications, nanoparticles must be biocompatible and targetable toward explicit receptors to guarantee particular detecting, imaging, and medication conveyance in complex organic milieus, for example, living cells, tissues, and organisms. We present recent works that explore enhanced biocompatibility and biorecognition of nanoparticles functionalized with DNA and different DNA entities such as aptamers, DNAzymes, and aptazymes. We sum up the methods utilized in the amalgamation of complex nanostructures, survey the significant types of multifunctional nanoparticles that have been developed in the course of recent years, and give a perceptual vision of the significant field of nanomedicine. The field of DNA-functionalized nanoparticles holds an incredible guarantee in rising biomedical zones, for example, multimodal imaging, theranostics, and picture-guided treatments.