Antiviral inhibition of enveloped virus release by tetherin/BST-2: action and counteraction

Tetherin (BST2/CD317) has been recently recognized as a potent interferon-induced antiviral molecule that inhibits the release of diverse mammalian enveloped virus particles from infected cells. By targeting an immutable structure common to all these viruses, the virion membrane, evasion of this ant...

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Bibliographic Details
Published in:Viruses 2011-05, Vol.3 (5), p.520-540
Main Authors: Le Tortorec, Anna, Willey, Suzanne, Neil, Stuart J D
Format: Article
Language:English
Subjects:
Antigens, CD - genetics
Antigens, CD - metabolism
Down-Regulation
GPI-Linked Proteins - antagonists & inhibitors
GPI-Linked Proteins - genetics
GPI-Linked Proteins - metabolism
HIV - genetics
HIV - physiology
HIV Infections - genetics
HIV Infections - metabolism
HIV Infections - virology
Humans
interferon
Life Sciences
Protein Binding
restriction of enveloped virus release
Review
Tetherin/BST2
viral countermeasure
Viral Proteins - genetics
Viral Proteins - metabolism
Virus Release
Vpu
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Summary:Tetherin (BST2/CD317) has been recently recognized as a potent interferon-induced antiviral molecule that inhibits the release of diverse mammalian enveloped virus particles from infected cells. By targeting an immutable structure common to all these viruses, the virion membrane, evasion of this antiviral mechanism has necessitated the development of specific countermeasures that directly inhibit tetherin activity. Here we review our current understanding of the molecular basis of tetherin's mode of action, the viral countermeasures that antagonize it, and how virus/tetherin interactions may affect viral transmission and pathogenicity.
ISSN:1999-4915
1999-4915
DOI:10.3390/v3050520