Disrupted association between structural and functional coupling of the supplementary motor area and neurocognition in major depressive disorder

• Published in: Chinese medical journal 2023-09, Vol.136 (17), p.2131-2133
• Main Authors: Wei, Jinxue, Wang, Yu, Zhang, Zijian, Yang, Xiao, Zhao, Liansheng, Ni, Peiyan, Ni, Rongjun, Ma, Xiaohong
• Format: Article
• Language: English
• Subjects: Age; Automation; Brain; Correspondence; Disease; Education; Gender; Intelligence tests; Males; Mental depression; Pathophysiology; Psychosis
• ISSN: 2542-5641; 0366-6999; 2542-5641
• DOI: 10.1097/CM9.0000000000002614

[...]the structural-functional connectivity (SC-FC) relationship is strengthened with age, which is consistent with the finding that significant correlations along intra-hemispheric tracts are observed between structural connectivity and functional connectivity in adults but not in children. [...]the maturation of some functional connections in the default-mode network precedes that of structural connectivity. Han Chinese participants aged 16 to 55 years who met the criteria of MDD as specified in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) were recruited from the Mental Health Center of West China Hospital of Sichuan University. The Benjamini–Hochberg procedure was used to control false discovery rates (FDRs) of multiple tests in comparing SC-FC coupling and correlation coefficients between patients with MDD and HCs. There was a statistically significant difference in correlation coefficients between SC-FC coupling of SMA_R and DMS_MCL_S in patients with MDD and HCs (P