Endothelial dysfunction in children with chronic kidney disease

Cardiovascular disease (CVD) is the main cause of death in children with chronic kidney disease (CKD). Inflammation and endothelial dysfunction (ED) are found in the majority of these patients and are factors associated to CVD. Flow mediated dilatation (FMD) is a surrogate marker validated for evalu...

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Bibliographic Details
Published in:Nefrología 2021-07, Vol.41 (4), p.436-445
Main Authors: García-Bello, Juan Antonio, Gómez-Díaz, Rita A., Contreras-Rodríguez, Alicia, Sánchez-Barbosa, Lorena, Mondragón-González, Rafael, Gallardo-Montoya, Juan Manuel, Wacher, Niels H.
Format: Article
Language:English
Subjects:
Cardiovascular disease
Chronic kidney disease
Dilatación mediada por flujo
Disfunción endotelial
Endothelial dysfunction
Enfermedad cardiovascular
Enfermedad renal crónica
Flow mediated dilatation
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Summary:Cardiovascular disease (CVD) is the main cause of death in children with chronic kidney disease (CKD). Inflammation and endothelial dysfunction (ED) are found in the majority of these patients and are factors associated to CVD. Flow mediated dilatation (FMD) is a surrogate marker validated for evaluating ED. Our objective was to identify risk factors associated to ED in children with CKD. Children 2–16 years of age were studied. Clinical information and biochemical variables were gathered, including intact parathyroid hormone (iPTH), interleukins 6 and 1b, high sensitivity C reactive protein (hsCRP), reduced glutathione, nitric oxide, malondialdehyde and homocysteine. FMD was measured, and considered altered if
ISSN:2013-2514
2013-2514
DOI:10.1016/j.nefroe.2020.10.002