Genome-wide association study of personality traits in the long life family study

Personality traits have been shown to be associated with longevity and healthy aging. In order to discover novel genetic modifiers associated with personality traits as related with longevity, we performed a genome-wide association study (GWAS) on personality factors assessed by NEO-five-factor inve...

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Bibliographic Details
Published in:Frontiers in genetics 2013, Vol.4, p.65
Main Authors: Bae, Harold T, Sebastiani, Paola, Sun, Jenny X, Andersen, Stacy L, Daw, E Warwick, Terracciano, Antonio, Ferrucci, Luigi, Perls, Thomas T
Format: Article
Language:English
Subjects:
family study
gene-environment interaction
Genetics
GWAS
Longevity
neo scores
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Summary:Personality traits have been shown to be associated with longevity and healthy aging. In order to discover novel genetic modifiers associated with personality traits as related with longevity, we performed a genome-wide association study (GWAS) on personality factors assessed by NEO-five-factor inventory in individuals enrolled in the Long Life Family Study (LLFS), a study of 583 families (N up to 4595) with clustering for longevity in the United States and Denmark. Three SNPs, in almost perfect LD, associated with agreeableness reached genome-wide significance (p 
ISSN:1664-8021
1664-8021
DOI:10.3389/fgene.2013.00065