Synthesis and Characterization of Photoluminescent Ce(III) and Ce(IV) Substituted Hydroxyapatite Nanomaterials by Co-Precipitation Method: Cytotoxicity and Biocompatibility Evaluation

Improved compounds of Ce(III) and Ce(IV)-doped hydroxyapatite (Ca10-xCex(PO4)6(OH)2) with different concentrations such as x = 0.5, 1, 2.5, 5, and 10%, obtained by the simple co-precipitation method were synthesized. The cerium (3+) and cerium (4+)-doped hydroxyapatite were evaluated for biocompatib...

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Bibliographic Details
Published in:Nanomaterials (Basel, Switzerland) Switzerland), 2021-07, Vol.11 (8), p.1911
Main Authors: Paduraru, Andrei Viorel, Musuc, Adina Magdalena, Oprea, Ovidiu Cristian, Trusca, Roxana, Iordache, Florin, Vasile, Bogdan Stefan, Andronescu, Ecaterina
Format: Article
Language:English
Subjects:
Antibiotics
Aqueous solutions
Biocompatibility
biocompatibility evaluation
Biological properties
Calcium phosphates
Cerium
cerium ions
Chemical precipitation
Coprecipitation
Cytotoxicity
Fluorescence
Fourier transforms
Hydroxyapatite
Investigations
Morphology
Nanomaterials
Nanoparticles
Nanotechnology
Nitrates
Photoluminescence
Scanning electron microscopy
Spectrometry
Synthesis
Toxicity
Ultraviolet spectroscopy
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Summary:Improved compounds of Ce(III) and Ce(IV)-doped hydroxyapatite (Ca10-xCex(PO4)6(OH)2) with different concentrations such as x = 0.5, 1, 2.5, 5, and 10%, obtained by the simple co-precipitation method were synthesized. The cerium (3+) and cerium (4+)-doped hydroxyapatite were evaluated for biocompatibility and fluorescence properties. It was found that the cerium-HAp powders were non-toxic, even at higher level of concentration. The synthesized powders were further characterized by FTIR spectrometry, UV-Vis spectroscopy, XRD diffraction, SEM and TEM analysis. Therefore, the present study proves that the developed cerium (3+) and cerium (4+)-doped hydroxyapatite, respectively can be widely used as luminescent labeling materials, with improved biological properties.
ISSN:2079-4991
2079-4991
DOI:10.3390/nano11081911