Interleukin-19 in Breast Cancer

Inflammatory cytokines within the tumor microenvironment are linked to progression in breast cancer. Interleukin- (IL-) 19, part of the IL-10 family, contributes to a range of diseases and disorders, such as asthma, endotoxic shock, uremia, psoriasis, and rheumatoid arthritis. IL-19 is expressed in...

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Bibliographic Details
Published in:Clinical & developmental immunology 2013-01, Vol.2013 (2013), p.1-9
Main Authors: Chang, Ming-Shi, Yeh, Ching-Hua, Li, Chien-Feng, Chen, Ying-Yin, Hsing, Chung-Hsi
Format: Article
Language:English
Subjects:
Biomarkers - metabolism
Breast cancer
Breast Neoplasms - diagnosis
Breast Neoplasms - immunology
Breast Neoplasms - mortality
Breast Neoplasms - pathology
Carcinoma, Ductal, Breast - diagnosis
Carcinoma, Ductal, Breast - immunology
Carcinoma, Ductal, Breast - mortality
Carcinoma, Ductal, Breast - pathology
Cell Movement
Cell Proliferation
Colleges & universities
Disease Progression
Female
Gene Expression
Humans
Immunology
Interleukins - genetics
Interleukins - immunology
Neoplasm Metastasis
Prognosis
Review
Rodents
Survival Analysis
Tumor Microenvironment - immunology
Tumors
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Summary:Inflammatory cytokines within the tumor microenvironment are linked to progression in breast cancer. Interleukin- (IL-) 19, part of the IL-10 family, contributes to a range of diseases and disorders, such as asthma, endotoxic shock, uremia, psoriasis, and rheumatoid arthritis. IL-19 is expressed in several types of tumor cells, especially in squamous cell carcinoma of the skin, tongue, esophagus, and lung and invasive duct carcinoma of the breast. In breast cancer, IL-19 expression is correlated with increased mitotic figures, advanced tumor stage, higher metastasis, and poor survival. The mechanisms of IL-19 in breast cancer have recently been explored both in vitro and in vivo. IL-19 has an autocrine effect in breast cancer cells. It directly promotes proliferation and migration and indirectly provides a microenvironment for tumor progression, which suggests that IL-19 is a prognostic marker in breast cancer and that antagonizing IL-19 may have therapeutic potential.
ISSN:2314-8861
1740-2522
2314-7156
1740-2530
DOI:10.1155/2013/294320