Does priming with sex steroids improve the diagnosis of normal growth hormone secretion in short children?

There is still controversy for priming with sex steroid before growth hormone (GH) testing. We studied GH response to stimulation in 92 children >9 years with idiopathic short stature (height standard deviation score [HtSDS]-2). They were divided randomly into two groups. Children in Group 1 (n =...

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Bibliographic Details
Published in:Indian journal of endocrinology and metabolism 2014-11, Vol.18 (Suppl 1), p.S80-S83
Main Authors: Soliman, Ashraf, Adel, Ashraf, Sabt, Aml, Elbukhari, Elkhansa, Ahmed, Hannah, De Sanctis, Vincenzo
Format: Article
Language:English
Subjects:
Estradiol
growth hormone testing
Growth hormones
Insulin-like growth factors
Measurement
Original
Physical growth
Physiological aspects
Pituitary gland
Properties
sex-steroid priming
Somatotropin
Stature, Short
Steroid hormones
Steroids
testosterone
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Summary:There is still controversy for priming with sex steroid before growth hormone (GH) testing. We studied GH response to stimulation in 92 children >9 years with idiopathic short stature (height standard deviation score [HtSDS]-2). They were divided randomly into two groups. Children in Group 1 (n = 50) were primed with premarin in girls and testosterone in boys and those in Group 2 were not primed (n = 42). All children were tested using standard clonidine test and their serum insulin-like growth factor-I concentration (IGF-I). Additionally the growth and GH-IGF-I data of the two groups of children were compared with those for 32 short children (HtSDS 9 years. The peak GH response to clonidine provocation test did not differ before (n = 42) versus after 9 years (n = 32) of age. In this randomized study priming with sex steroids before GH testing did not significantly increase the yield of diagnosing short patients with normal GH secretion. In addition, GH response to provocation did not vary significantly between young (9 years) short children.
ISSN:2230-8210
2230-9500
DOI:10.4103/2230-8210.145078