NLRP3 polymorphism is associated with protection against human T-lymphotropic virus 1 infection

• Published in: Memórias do Instituto Oswaldo Cruz 2014-11, Vol.109 (7), p.960-960
• Main Authors: Kamada, Anselmo Jiro, Pontillo, Alessandra, Guimarães, Rafael Lima, Loureiro, Paula, Crovella, Sergio, Brandão, Lucas André Cavalcanti
• Format: Article
• Language: English
• Subjects: Adult; Brazil; Carrier Proteins - genetics; Carrier Proteins - metabolism; Female; Genetic Predisposition to Disease; HTLV-1; HTLV-I Infections - genetics; HTLV-I Infections - immunology; Human T-lymphotropic virus 1 - genetics; Humans; Inflammasomes - immunology; innate immunity; Interleukin-1 - metabolism; Male; Middle Aged; NLR Family, Pyrin Domain-Containing 3 Protein; NLRP1; NLRP3; PARASITOLOGY; Polymorphism, Single Nucleotide - genetics; Protective Factors; Short Communication; single nucleotide polymorphisms; TROPICAL MEDICINE
• ISSN: 0074-0276; 1678-8060; 1678-8060; 0074-0276
• DOI: 10.1590/0074-0276140154

Inter-individual heterogeneity in the response to human T-lymphotropic virus 1 (HTLV-1) infection has been partially attributed to host genetic background. The antiviral activity of the inflammasome cytoplasmic complex recognises viral molecular patterns and regulates immune responses via the activation of interleukin (IL)-1 family (IL-1, IL-18 and IL-33) members. The association between polymorphisms in the inflammasome receptors NLRP1 and NLRP3 and HTLV-1 infection was evaluated in a northeastern Brazilian population (84 HTLV-1 carriers and 155 healthy controls). NLRP3 rs10754558 G/G was associated with protection against HTLV-1 infection (p = 0.012; odds ratio = 0.37). rs10754558 affects NLRP3 mRNA stability; therefore, our results suggest that higher NLRP3 expression may augment first-line defences, leading to the effective protection against HTLV-1 infection.