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Biocompatibility and Antibacterial Properties of ZnO-Incorporated Anodic Oxide Coatings on TiZrNb Alloy
In a present paper, we demonstrate novel approach to form ceramic coatings with incorporated ZnO nanoparticles (NPs) on low modulus TiZrNb alloy with enhanced biocompatibility and antibacterial parameters. Plasma Electrolytic Oxidation (PEO) was used to integrate ZnO nanoparticles (average size 12-2...
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| Published in: | Nanomaterials (Basel, Switzerland) Switzerland), 2020-11, Vol.10 (12), p.2401 |
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| creator | Oleshko, Oleksandr Husak, Yevheniia Korniienko, Viktoriia Pshenychnyi, Roman Varava, Yuliia Kalinkevich, Oksana Pisarek, Marcin Grundstains, Karlis Pogorielova, Oksana Mishchenko, Oleg Simka, Wojciech Viter, Roman Pogorielov, Maksym |
| description | In a present paper, we demonstrate novel approach to form ceramic coatings with incorporated ZnO nanoparticles (NPs) on low modulus TiZrNb alloy with enhanced biocompatibility and antibacterial parameters. Plasma Electrolytic Oxidation (PEO) was used to integrate ZnO nanoparticles (average size 12-27 nm), mixed with Ca(H
PO
)
aqueous solution into low modulus TiZrNb alloy surface. The TiZrNb alloys with integrated ZnO NPs successfully showed higher surface porosity and contact angle. XPS investigations showed presence of Ca ions and absence of phosphate ions in the PEO modified layer, what explains higher values of contact angle. Cell culture experiment (U2OS type) confirmed that the surface of as formed oxide-ZnO NPs demonstrated hydrophobic properties, what can affect primary cell attachment. Further investigations showed that Ca ions in the PEO coating stimulated proliferative activity of attached cells, resulting in competitive adhesion between cells and bacteria in clinical situation. Thus, high contact angle and integrated ZnO NPs prevent bacterial adhesion and considerably enhance the antibacterial property of TiZrNb alloys. A new anodic oxide coating with ZnO NPs could be successfully used for modification of low modulus alloys to decrease post-implantation complications. |
| doi_str_mv | 10.3390/nano10122401 |
| format | article |
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PO
)
aqueous solution into low modulus TiZrNb alloy surface. The TiZrNb alloys with integrated ZnO NPs successfully showed higher surface porosity and contact angle. XPS investigations showed presence of Ca ions and absence of phosphate ions in the PEO modified layer, what explains higher values of contact angle. Cell culture experiment (U2OS type) confirmed that the surface of as formed oxide-ZnO NPs demonstrated hydrophobic properties, what can affect primary cell attachment. Further investigations showed that Ca ions in the PEO coating stimulated proliferative activity of attached cells, resulting in competitive adhesion between cells and bacteria in clinical situation. Thus, high contact angle and integrated ZnO NPs prevent bacterial adhesion and considerably enhance the antibacterial property of TiZrNb alloys. A new anodic oxide coating with ZnO NPs could be successfully used for modification of low modulus alloys to decrease post-implantation complications.</description><identifier>ISSN: 2079-4991</identifier><identifier>EISSN: 2079-4991</identifier><identifier>DOI: 10.3390/nano10122401</identifier><identifier>PMID: 33266240</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adhesion ; Alloys ; Anodic coatings ; antibacterial properties ; Aqueous solutions ; Bacteria ; Biocompatibility ; Calcium ions ; Cell adhesion ; Cell adhesion & migration ; Cell culture ; Ceramic coatings ; Ceramic glazes ; Coatings ; Contact angle ; Electrolytes ; Electrolytic cells ; Hydrophobicity ; Ions ; Microorganisms ; Nanoparticles ; Oxidation ; Oxide coatings ; Phosphates ; plasma electrolytic oxidation ; Porosity ; Protective coatings ; Scanning electron microscopy ; Spectrum analysis ; Titanium alloys ; TiZrNb alloy ; Transplants & implants ; Zinc oxide ; Zinc oxides ; ZnO nanoparticles</subject><ispartof>Nanomaterials (Basel, Switzerland), 2020-11, Vol.10 (12), p.2401</ispartof><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-3c76ab313a3ac78c29eadc7bf8a4d09a9e1e14ed9831c07d7a10c9aecefc0b023</citedby><cites>FETCH-LOGICAL-c478t-3c76ab313a3ac78c29eadc7bf8a4d09a9e1e14ed9831c07d7a10c9aecefc0b023</cites><orcidid>0000-0003-2439-3243 ; 0000-0002-5144-2138 ; 0000-0002-4793-7568 ; 0000-0001-9372-7791 ; 0000-0002-2560-9379 ; 0000-0002-7424-5954 ; 0000-0002-2217-3717 ; 0000-0002-2648-5523</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2467258069/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2467258069?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25731,27901,27902,36989,36990,44566,53766,53768,74869</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33266240$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oleshko, Oleksandr</creatorcontrib><creatorcontrib>Husak, Yevheniia</creatorcontrib><creatorcontrib>Korniienko, Viktoriia</creatorcontrib><creatorcontrib>Pshenychnyi, Roman</creatorcontrib><creatorcontrib>Varava, Yuliia</creatorcontrib><creatorcontrib>Kalinkevich, Oksana</creatorcontrib><creatorcontrib>Pisarek, Marcin</creatorcontrib><creatorcontrib>Grundstains, Karlis</creatorcontrib><creatorcontrib>Pogorielova, Oksana</creatorcontrib><creatorcontrib>Mishchenko, Oleg</creatorcontrib><creatorcontrib>Simka, Wojciech</creatorcontrib><creatorcontrib>Viter, Roman</creatorcontrib><creatorcontrib>Pogorielov, Maksym</creatorcontrib><title>Biocompatibility and Antibacterial Properties of ZnO-Incorporated Anodic Oxide Coatings on TiZrNb Alloy</title><title>Nanomaterials (Basel, Switzerland)</title><addtitle>Nanomaterials (Basel)</addtitle><description>In a present paper, we demonstrate novel approach to form ceramic coatings with incorporated ZnO nanoparticles (NPs) on low modulus TiZrNb alloy with enhanced biocompatibility and antibacterial parameters. Plasma Electrolytic Oxidation (PEO) was used to integrate ZnO nanoparticles (average size 12-27 nm), mixed with Ca(H
PO
)
aqueous solution into low modulus TiZrNb alloy surface. The TiZrNb alloys with integrated ZnO NPs successfully showed higher surface porosity and contact angle. XPS investigations showed presence of Ca ions and absence of phosphate ions in the PEO modified layer, what explains higher values of contact angle. Cell culture experiment (U2OS type) confirmed that the surface of as formed oxide-ZnO NPs demonstrated hydrophobic properties, what can affect primary cell attachment. Further investigations showed that Ca ions in the PEO coating stimulated proliferative activity of attached cells, resulting in competitive adhesion between cells and bacteria in clinical situation. Thus, high contact angle and integrated ZnO NPs prevent bacterial adhesion and considerably enhance the antibacterial property of TiZrNb alloys. A new anodic oxide coating with ZnO NPs could be successfully used for modification of low modulus alloys to decrease post-implantation complications.</description><subject>Adhesion</subject><subject>Alloys</subject><subject>Anodic coatings</subject><subject>antibacterial properties</subject><subject>Aqueous solutions</subject><subject>Bacteria</subject><subject>Biocompatibility</subject><subject>Calcium ions</subject><subject>Cell adhesion</subject><subject>Cell adhesion & migration</subject><subject>Cell culture</subject><subject>Ceramic coatings</subject><subject>Ceramic glazes</subject><subject>Coatings</subject><subject>Contact angle</subject><subject>Electrolytes</subject><subject>Electrolytic cells</subject><subject>Hydrophobicity</subject><subject>Ions</subject><subject>Microorganisms</subject><subject>Nanoparticles</subject><subject>Oxidation</subject><subject>Oxide coatings</subject><subject>Phosphates</subject><subject>plasma electrolytic oxidation</subject><subject>Porosity</subject><subject>Protective coatings</subject><subject>Scanning electron microscopy</subject><subject>Spectrum analysis</subject><subject>Titanium alloys</subject><subject>TiZrNb alloy</subject><subject>Transplants & implants</subject><subject>Zinc oxide</subject><subject>Zinc oxides</subject><subject>ZnO 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ZnO-Incorporated Anodic Oxide Coatings on TiZrNb Alloy</atitle><jtitle>Nanomaterials (Basel, Switzerland)</jtitle><addtitle>Nanomaterials (Basel)</addtitle><date>2020-11-30</date><risdate>2020</risdate><volume>10</volume><issue>12</issue><spage>2401</spage><pages>2401-</pages><issn>2079-4991</issn><eissn>2079-4991</eissn><abstract>In a present paper, we demonstrate novel approach to form ceramic coatings with incorporated ZnO nanoparticles (NPs) on low modulus TiZrNb alloy with enhanced biocompatibility and antibacterial parameters. Plasma Electrolytic Oxidation (PEO) was used to integrate ZnO nanoparticles (average size 12-27 nm), mixed with Ca(H
PO
)
aqueous solution into low modulus TiZrNb alloy surface. The TiZrNb alloys with integrated ZnO NPs successfully showed higher surface porosity and contact angle. XPS investigations showed presence of Ca ions and absence of phosphate ions in the PEO modified layer, what explains higher values of contact angle. Cell culture experiment (U2OS type) confirmed that the surface of as formed oxide-ZnO NPs demonstrated hydrophobic properties, what can affect primary cell attachment. Further investigations showed that Ca ions in the PEO coating stimulated proliferative activity of attached cells, resulting in competitive adhesion between cells and bacteria in clinical situation. Thus, high contact angle and integrated ZnO NPs prevent bacterial adhesion and considerably enhance the antibacterial property of TiZrNb alloys. A new anodic oxide coating with ZnO NPs could be successfully used for modification of low modulus alloys to decrease post-implantation complications.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>33266240</pmid><doi>10.3390/nano10122401</doi><orcidid>https://orcid.org/0000-0003-2439-3243</orcidid><orcidid>https://orcid.org/0000-0002-5144-2138</orcidid><orcidid>https://orcid.org/0000-0002-4793-7568</orcidid><orcidid>https://orcid.org/0000-0001-9372-7791</orcidid><orcidid>https://orcid.org/0000-0002-2560-9379</orcidid><orcidid>https://orcid.org/0000-0002-7424-5954</orcidid><orcidid>https://orcid.org/0000-0002-2217-3717</orcidid><orcidid>https://orcid.org/0000-0002-2648-5523</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Nanomaterials (Basel, Switzerland), 2020-11, Vol.10 (12), p.2401 |
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| source | Publicly Available Content Database; PubMed Central |
| subjects | Adhesion Alloys Anodic coatings antibacterial properties Aqueous solutions Bacteria Biocompatibility Calcium ions Cell adhesion Cell adhesion & migration Cell culture Ceramic coatings Ceramic glazes Coatings Contact angle Electrolytes Electrolytic cells Hydrophobicity Ions Microorganisms Nanoparticles Oxidation Oxide coatings Phosphates plasma electrolytic oxidation Porosity Protective coatings Scanning electron microscopy Spectrum analysis Titanium alloys TiZrNb alloy Transplants & implants Zinc oxide Zinc oxides ZnO nanoparticles |
| title | Biocompatibility and Antibacterial Properties of ZnO-Incorporated Anodic Oxide Coatings on TiZrNb Alloy |
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