New Iridoid Derivatives from the Fruits of Cornus officinalis and Their Neuroprotective Activities

Three previously undescribed iridoids, cornusfurals A⁻C, were isolated from the ethanolic extracts of fruits of . Their structures were elucidated by spectroscopic methods, including one-dimensional and two-dimensional nuclear magnetic resonance, ultraviolet spectroscopy, infrared spectroscopy, and...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2019-02, Vol.24 (3), p.625
Main Authors: Ji, Lin-Lin, Wang, Xin, Li, Jin-Jie, Zhong, Xiang-Jian, Zhang, Bo, Juan, Jing, Shang, Xiao-Ya
Format: Article
Language:English
Subjects:
Chromatography
Cornus officinalis
Corticosterone
Ethanol
Fruits
Infrared spectroscopy
iridoid
Mass spectrometry
Mass spectroscopy
Neuroprotection
neuroprotective activity
NMR
Nuclear magnetic resonance
Pheochromocytoma cells
Ultraviolet spectroscopy
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Summary:Three previously undescribed iridoids, cornusfurals A⁻C, were isolated from the ethanolic extracts of fruits of . Their structures were elucidated by spectroscopic methods, including one-dimensional and two-dimensional nuclear magnetic resonance, ultraviolet spectroscopy, infrared spectroscopy, and mass spectrometry. The neuroprotective activity was evaluated by measuring corticosterone-induced damage in PC12 cells. The results showed that cornusfural B decreased corticosterone-induced PC12 cell damage compared with that in model cells.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules24030625