Autonomic Responses during Labor: Potential Implications for Takotsubo Syndrome

Takotsubo syndrome is a serious complication of labor. Although the pathophysiologic role of excessive sympathetic activation is established in this process, concurrent vagal responses have not been adequately described. Moreover, it remains unclear whether autonomic activity depends on the mode of...

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Bibliographic Details
Published in:Journal of cardiovascular development and disease 2021-11, Vol.8 (11), p.152
Main Authors: Papadopoulos, Georgios E., Evaggelou, Theoxaris I., Moulias, Errikos K., Tsonis, Orestis, Zekios, Konstantinos C., Nikas, Dimitrios N., Tzimas, Petros, Paschopoulos, Minas, Kolettis, Theofilos M.
Format: Article
Language:English
Subjects:
Cardiovascular disease
cesarean delivery
Cesarean section
Childbirth & labor
Diabetes
General anesthesia
Heart rate
Hypotheses
Sinuses
sympathetic responses
vagal responses
Vagina
vaginal delivery
Variables
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Summary:Takotsubo syndrome is a serious complication of labor. Although the pathophysiologic role of excessive sympathetic activation is established in this process, concurrent vagal responses have not been adequately described. Moreover, it remains unclear whether autonomic activity depends on the mode of delivery. Here, we explored the hypothesis that the different management of cesarean and vaginal delivery may elicit diverse responses affecting both autonomic arms. For this aim, continuous electrocardiographic recording was performed in 20 women during labor, and non-invasive indices of sympathetic and vagal activity were compared between the two modes of delivery. We report sympathetic prevalence during cesarean delivery, caused by marked vagal withdrawal, whereas autonomic activity was rather stable during vaginal delivery. These differences may be attributed to the effects of anesthesia during cesarean delivery, along with the protective effects of oxytocin administration during vaginal delivery. Our results provide further insights on autonomic responses during labor that may prove useful in the prevention of complications, such as takotsubo syndrome.
ISSN:2308-3425
2308-3425
DOI:10.3390/jcdd8110152