Resistance to amoxicillin, clarithromycin and ciprofloxacin of Helicobacter pylori isolated from Southern Brazil patients

Helicobacter pylori is a bacteria which infects half the world population and is an important cause of gastric cancer. The eradication therapy is not always effective because resistance to antimicrobials may occur. The aim of this study was to determine the susceptibility profile of H. pylori to amo...

Full description

Saved in:
Bibliographic Details
Published in:Revista do Instituto de Medicina Tropical de São Paulo 2014-05, Vol.56 (3), p.197-200
Main Authors: Picoli, Simone Ulrich, Mazzoleni, Luiz Edmundo, Fernández, Heriberto, De Bona, Laura Renata, Neuhauss, Erli, Longo, Larisse, Prolla, João Carlos
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Amoxicillin
Amoxicillin - pharmacology
Anti-Bacterial Agents - pharmacology
Antibiotic resistance
Ciprofloxacin
Ciprofloxacin - pharmacology
Clarithromycin
Clarithromycin - pharmacology
Drug Resistance, Bacterial
Helicobacter Infections - microbiology
Helicobacter pylori
Helicobacter pylori - drug effects
Helicobacter pylori - isolation & purification
Humans
Microbial Sensitivity Tests
Middle Aged
TROPICAL MEDICINE
Virology
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Helicobacter pylori is a bacteria which infects half the world population and is an important cause of gastric cancer. The eradication therapy is not always effective because resistance to antimicrobials may occur. The aim of this study was to determine the susceptibility profile of H. pylori to amoxicillin, clarithromycin and ciprofloxacin in the population of Southern Brazil. Fifty four samples of H. pylori were evaluated. The antibiotics susceptibility was determined according to the guidelines of the British Society for Antimicrobial Chemotherapy and the Comité de l'Antibiogramme de la Société Française de Microbiologie. Six (11.1%) H. pylori isolates were resistant to clarithromycin, one (1.9%) to amoxicillin and three (5.5%) to ciprofloxacin. These indices of resistance are considered satisfactory and show that all of these antibiotics can be used in the empirical therapy. The antibiotics amoxicillin and clarithromycin are still a good option for first line anti-H. pylori treatment in the population of Southern Brazil.
ISSN:0036-4665
1678-9946
1678-9946
0036-4665
DOI:10.1590/S0036-46652014000300003