Lipid Profiles from Dried Blood Spots Reveal Lipidomic Signatures of Newborns Undergoing Mild Therapeutic Hypothermia after Hypoxic-Ischemic Encephalopathy

Hypoxic-ischemic encephalopathy (HIE) is associated with perinatal brain injury, which may lead to disability or death. As the brain is a lipid-rich organ, various lipid species can be significantly impacted by HIE and these correlate with specific changes to the lipidomic profile in the circulation...

Full description

Saved in:
Bibliographic Details
Published in:Nutrients 2021-11, Vol.13 (12), p.4301
Main Authors: Nixon, Rebekah, Ip, Ting Hin Richard, Jenkins, Benjamin, Yip, Ping K, Clarke, Paul, Ponnusamy, Vennila, Michael-Titus, Adina T, Koulman, Albert, Shah, Divyen K
Format: Article
Language:English
Subjects:
Automation
Biomarkers
Blood circulation
brain
Brain damage
Brain injury
Discriminant analysis
dried blood spot
Dried Blood Spot Testing
Encephalopathy
Female
Humans
Hypothermia
Hypothermia, Induced
Hypoxia
Hypoxia-Ischemia, Brain - blood
Hypoxia-Ischemia, Brain - therapy
hypoxic-ischemic encephalopathy
Infant, Newborn
Ischemia
Lecithin
Lipidomics
Lipids
Lipids - blood
Lysophosphatidylcholine
Male
Mass spectrometry
Medical screening
Modelling
Multivariate analysis
Neonates
Neuroprotection
newborn
Newborn babies
Nutrition
Peripheral blood
Phosphatidylcholine
Scientific imaging
Signal transduction
Sphingomyelin
therapeutic hypothermia
Traumatic brain injury
Triglycerides
Umbilical cord
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hypoxic-ischemic encephalopathy (HIE) is associated with perinatal brain injury, which may lead to disability or death. As the brain is a lipid-rich organ, various lipid species can be significantly impacted by HIE and these correlate with specific changes to the lipidomic profile in the circulation. Objective: To investigate the peripheral blood lipidomic signature in dried blood spots (DBS) from newborns with HIE. Using univariate analysis, multivariate analysis and sPLS-DA modelling, we show that newborns with moderate-severe HIE ( = 46) who underwent therapeutic hypothermia (TH) displayed a robust peripheral blood lipidomic signature comprising 29 lipid species in four lipid classes; namely phosphatidylcholine (PC), lysophosphatidylcholine (LPC), triglyceride (TG) and sphingomyelin (SM) when compared with newborns with mild HIE ( = 18). In sPLS-DA modelling, the three most discriminant lipid species were TG 50:3, TG 54:5, and PC 36:5. We report a reduction in plasma TG and SM and an increase in plasma PC and LPC species during the course of TH in newborns with moderate-severe HIE, compared to a single specimen from newborns with mild HIE. These findings may guide the research in nutrition-based intervention strategies after HIE in synergy with TH to enhance neuroprotection.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu13124301