Risk factors for postoperative hepatic dysfunction in overweight patients with acute type A aortic dissection

• Published in: BMC surgery 2024-10, Vol.24 (1), p.305-7, Article 305
• Main Authors: Xu, Yu, Liu, Lin-Zhuo, Lu, Hong-Qiao, Yang, Xin-Qing, Guo, Shi-Kui, Tang, Yong-Jiang, Gong, Kun-Mei
• Format: Article
• Language: English
• Subjects: Acute Disease; Acute hepatic dysfunction; Adult; Aged; Aorta; Aortic dissection; Aortic Dissection - complications; Aortic Dissection - surgery; ATAAD; Blood; Body mass index; Body weight; Complications; Creatinine; Diabetes; Dissection; Electrolytes; Female; Females; Hemorrhagic shock; Hospitals; Humans; Hypertension; Incidence; Infections; Kidney diseases; Liver; Liver Diseases - complications; Lymphocytes; Male; MELD score; Middle Aged; Morbidity; Mortality; Multivariate analysis; Neutrophils; Obesity; Overweight; Overweight - complications; Patients; Postoperative; Postoperative Complications - diagnosis; Postoperative Complications - epidemiology; Postoperative Complications - etiology; Regression analysis; Retrospective Studies; Risk Factors; ROC Curve; Surgery; Thrombocytopenia; Veins & arteries
• ISSN: 1471-2482; 1471-2482
• DOI: 10.1186/s12893-024-02621-x

Acute hepatic dysfunction (AHD) is a common postoperative complication in patients with acute type A aortic dissection. The aim of this study was to identify risk factors for acute hepatic dysfunction after surgery for acute type A aortic dissection. We performed a retrospective study from March 1, 2019, to February 28, 2021. The primary endpoints of this study were morbidity due to AHD and risk factors for incidence. Univariate analysis and multivariate logistic regression analysis were used to analyse the related factors, and receiver operating characteristic (ROC) curves were plotted to evaluate their predictive value. Among 147 patients, 29 (19.73%) developed postoperative acute hepatic dysfunction, and 9 (6.12%) died. Univariate analysis revealed that the ALT (P = 0.042), Cr (P  24) patients with ATAAD. The area under the ROC curve (AUC) for Cr was 0.745 > 0.7, indicating good predictive value. A high Cr concentration is an independent risk factor for postoperative AHD in overweight (BMI > 24) patients with ATAAD.