Isolation of Major Compounds and Gastroprotective Activity of Alchemilla Caucasica on Indomethacin Induced Gastric Ulcers in Rats

The genus, which belongs to the Rosaceae family, is known as Lady's mantle and is commonly used in traditional medicine. This study was designed to investigate the major metabolites isolation and gastroprotective effects of . Phytochemical studies were carried out using column chromatography on...

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Bibliographic Details
Published in:The Eurasian journal of medicine 2020-10, Vol.52 (3), p.249-253
Main Authors: Karaoglan, Esen Sezen, Bayir, Yasin, Albayrak, Abdulmecit, Toktay, Erdem, Ozgen, Ufuk, Kazaz, Cavit, Kahramanlar, Aysenur, Cadirci, Elif
Format: Article
Language:English
Subjects:
Alcohol industry
Antioxidants (Nutrients)
Herbal medicine
Indomethacin
Isoflavones
Medicinal plants
Metabolites
Original
Superoxides
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Summary:The genus, which belongs to the Rosaceae family, is known as Lady's mantle and is commonly used in traditional medicine. This study was designed to investigate the major metabolites isolation and gastroprotective effects of . Phytochemical studies were carried out using column chromatography on . The gastroprotective effect of ethanol extract of this plant was tested on indomethacin-induced gastric ulcer model in rats. In addition, superoxide dismutase (SOD), malondialdehyde (MDA), and glutathione (GSH) parameters in the stomach tissue were examined. Quercetin-3-O-glucuronide, apigenin, and catechin were isolated from aerial parts of . When macroscopic ulcer index and histopathological results were analyzed, the extract at 200 mg/kg dose was found to be most effective. All doses of extract reduced MDA level and enhanced SOD activity and GSH level. The results of this study showed that has significant antiulcer activity. This effect was thought to be caused by antioxidant properties of flavonoids.
ISSN:1308-8734
1308-8742
1308-8742
DOI:10.5152/eurasianjmed.2020.19243