Clinical and Biomarker Profile Responses to Rehabilitation Treatment in Patients with Long COVID Characterized by Chronic Fatigue

Long COVID (LC) syndrome is a complex multiorgan symptom that persists beyond >12 weeks after SARS-CoV-2 infection. The most frequently associated symptom is fatigue. Physical activity and exercise are recommended, although specific studies are lacking. The objectives of the present work are to a...

Full description

Saved in:
Bibliographic Details
Published in:Viruses 2023-06, Vol.15 (7), p.1452
Main Authors: Binetti, Jessica, Real, Monica, Renzulli, Marcela, Bertran, Laia, Riesco, David, Perpiñan, Carles, Mohedano, Alba, Segundo, Rosa San, Ortiz, Marta, Porras, José Antonio, Pineda, Daniela Rosanna, Auguet, Teresa
Format: Article
Language:English
Subjects:
Aerobics
Biological markers
Biomarkers
Blood pressure
Care and treatment
chronic fatigue
Chronic fatigue syndrome
COVID-19
Creatinine
Disease
Dyspnea
Exercise
Fatigue
Health aspects
Heart rate
Hospitals
Infections
Intervention
Long COVID
Medical research
Medicine, Experimental
Nervous system
Pathogenesis
Patient outcomes
Patients
Physical activity
Physical fitness
physical rehabilitation
Physical training
Physiological aspects
Rehabilitation
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Long COVID (LC) syndrome is a complex multiorgan symptom that persists beyond >12 weeks after SARS-CoV-2 infection. The most frequently associated symptom is fatigue. Physical activity and exercise are recommended, although specific studies are lacking. The objectives of the present work are to analyze the impact of a supervised exercise program on the clinical evolution of LC with fatigue patients and to identify whether certain circulating biomarkers could predict the response to rehabilitation. The rehabilitation treatment response was analyzed in 14 women diagnosed with LC and fatigue, based on the changes in the 6 min walk test and Borg/Fatigue Impact scales. Patients who showed improvement in the meters walked were considered "responders" to the therapy. A total of 65% of patients responded to the exercise program, with an improvement in the meters walked and in oxygen saturation, with stability in the percentage of meters walked. Participants with obesity and those double-vaccinated against SARS-CoV-2 presented a lower degree of fatigue. LC patients presented a favorable response to a supervised exercise program. Differences in creatinine and protein levels were observed between rehabilitation therapy "responders" and "nonresponders". A good state of protein nutrition was related to a better rehabilitation response. The results are promising regarding possible predictive biomarkers of rehabilitation response, such as creatinine.
ISSN:1999-4915
1999-4915
DOI:10.3390/v15071452