Expanded Polytetrafluoroethylene Membranes for Vascular Stent Coating: Manufacturing, Biomedical and Surgical Applications, Innovations and Case Reports

Coated stents are defined as innovative stents surrounded by a thin polymer membrane based on polytetrafluoroethylene (PTFE)useful in the treatment of numerous vascular pathologies. Endovascular methodology involves the use of such devices to restore blood flow in small-, medium- and large-calibre a...

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Bibliographic Details
Published in:Membranes (Basel) 2023-02, Vol.13 (2), p.240
Main Authors: Cassano, Roberta, Perri, Paolo, Esposito, Antonio, Intrieri, Francesco, Sole, Roberta, Curcio, Federica, Trombino, Sonia
Format: Article
Language:English
Subjects:
Aneurysms
Arteries
Barriers
Blood flow
Cardiovascular system
Case reports
Coatings
covered stent
Design and construction
Electric fields
Emergency medical services
Health aspects
Hyperplasia
Implants
Innovations
Lubricants & lubrication
Manufacturing
Materials
Medical innovations
membrane
Membranes
Membranes (Technology)
Multilayers
Packaging
Polymers
Polytetrafluoroethylene
PTFE
Review
Sintering
Stent (Surgery)
Stents
Struts
Technological change
Thromboembolism
Thrombosis
vascular disease
Vascular diseases
Veins & arteries
Viscoelasticity
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Summary:Coated stents are defined as innovative stents surrounded by a thin polymer membrane based on polytetrafluoroethylene (PTFE)useful in the treatment of numerous vascular pathologies. Endovascular methodology involves the use of such devices to restore blood flow in small-, medium- and large-calibre arteries, both centrally and peripherally. These membranes cross the stent struts and act as a physical barrier to block the growth of intimal tissue in the lumen, preventing so-called intimal hyperplasia and late stent thrombosis. PTFE for vascular applications is known as expanded polytetrafluoroethylene (e-PTFE) and it can be rolled up to form a thin multilayer membrane expandable by 4 to 5 times its original diameter. This membrane plays an important role in initiating the restenotic process because wrapped graft stent could be used as the treatment option for trauma devices during emergency situations and to treat a number of pathological vascular disease. In this review, we will investigate the multidisciplinary techniques used for the production of e-PTFE membranes, the advantages and disadvantages of their use, the innovations and the results in biomedical and surgery field when used to cover graft stents.
ISSN:2077-0375
2077-0375
DOI:10.3390/membranes13020240