Anti-Microbiota Vaccine Reduces Avian Malaria Infection Within Mosquito Vectors

Animal and human pathogens that are transmitted by arthropods are a global concern, particularly those vectored by mosquitoes (e.g., spp. and dengue virus). Vector microbiota may hold the key to vector-borne pathogen control, as mounting evidence suggests that the contributions of the vector microbi...

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Bibliographic Details
Published in:Frontiers in immunology 2022-03, Vol.13, p.841835-841835
Main Authors: Aželytė, Justė, Wu-Chuang, Alejandra, Žiegytė, Rita, Platonova, Elena, Mateos-Hernandez, Lourdes, Maye, Jennifer, Obregon, Dasiel, Palinauskas, Vaidas, Cabezas-Cruz, Alejandro
Format: Article
Language:English
Subjects:
Animals
anti-microbiota vaccines
avian malaria
Birds
Canaries
Culicidae
Escherichia coli
Immunology
Life Sciences
Malaria, Avian - epidemiology
Microbiota
Mosquito Vectors
mosquitoes
networks
Oocysts
Plasmodium
Vaccines
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Summary:Animal and human pathogens that are transmitted by arthropods are a global concern, particularly those vectored by mosquitoes (e.g., spp. and dengue virus). Vector microbiota may hold the key to vector-borne pathogen control, as mounting evidence suggests that the contributions of the vector microbiota to vector physiology and pathogen life cycle are so relevant that vectorial capacity cannot be understood without considering microbial communities within the vectors. Anti-tick microbiota vaccines targeting commensal bacteria of the vector microbiota alter vector feeding and modulate the taxonomic and functional profiles of vector microbiome, but their impact on vector-borne pathogen development within the vector has not been tested. In this study, we tested whether anti-microbiota vaccination in birds targeting Enterobacteriaceae within mosquito midguts modulates the mosquito microbiota and disrupt development in its natural vector . Domestic canaries ( ) were experimentally infected with and/or immunized with live vaccines containing different strains of . Immunization of birds induced -specific antibodies. The midgut microbial communities of mosquitoes fed on -infected and/or -immunized birds were different from those of mosquitoes fed on control birds. Notably, mosquito midgut microbiota modulation was associated with a significant decrease in the occurrence of oocysts and sporozoites in the midguts and salivary glands of , respectively. A significant reduction in the number of oocysts was also observed. These findings suggest that anti-microbiota vaccines can be used as a novel tool to control malaria transmission and potentially other vector-borne pathogens.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2022.841835