The Effect of Conjunctiva-Müller Muscle Resection on Tear Oxidative Stress Levels in Patients with Blepharoptosis

• Published in: Turk oftalmoloji gazetesi 2024-06, Vol.54 (3), p.133-139
• Main Authors: Sert, Seda, Arıcı, Ceyhun, Mergen, Burak, Balcı Ekmekçi, Özlem
• Format: Article
• Language: English
• Subjects: 8-Hydroxy-2'-Deoxyguanosine - metabolism; Adult; Aged; Aldehydes - metabolism; Biomarkers - metabolism; blepharoplasty; Blepharoplasty - methods; Blepharoptosis; Blepharoptosis - metabolism; Blepharoptosis - surgery; Care and treatment; Conjunctiva - metabolism; Conjunctiva - surgery; dermatochalasis; Enzyme-Linked Immunosorbent Assay; Enzymes; Female; Humans; Male; Middle Aged; Oculomotor Muscles - metabolism; Oculomotor Muscles - surgery; Original; Oxidative stress; Oxidative Stress - physiology; Prospective Studies; Surgery; tear film; Tears - metabolism
• ISSN: 1300-0659; 2149-8709; 2149-8695; 2149-8709; 2147-2661
• DOI: 10.4274/tjo.galenos.2024.02697

To examine changes in tear oxidative stress levels and tear film functions in patients with blepharoptosis and dermatochalasis following conjunctiva-Müller muscle resection (CMMR) and blepharoplasty surgeries. This prospective study included 32 healthy controls and 62 patients with blepharoptosis or dermatochalasis. CMMR surgery was performed in 20 eyes and upper blepharoplasty was performed in 42 eyes. Tear oxidative stress markers (8-hydroxy-2’-deoxyguanosine [8-OHdG] and 4-hydroxy-2-nonenal [4-HNE]) were quantified by enzyme-linked immunosorbent assay and tear film functions were evaluated preoperatively and at 1 and 6 months postoperatively. The same assessments were performed in the control group at the same time points. Preoperative tear 8-OHdG and 4-HNE levels were lower in healthy controls (52.8±13.5 ng/mL and 27.8±6.4 ng/mL, respectively) compared to patients with dermatochalasis (86.1±37.2 ng/mL and 29.8±11.1 ng/mL, respectively) and blepharoptosis (90.4±39.3 ng/mL and 43.1±4.2 ng/mL, respectively) (p