Current Status of Amino Acid-Based Permeation Enhancers in Transdermal Drug Delivery

Transdermal drug delivery (TDD) presents many advantages compared to other conventional routes of drug administration, yet its full potential has not been achieved. The administration of drugs through the skin is hampered by the natural barrier properties of the skin, which results in poor permeatio...

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Bibliographic Details
Published in:Membranes (Basel) 2021-05, Vol.11 (5), p.343
Main Authors: Pereira, Rui, Silva, Sandra G, Pinheiro, Marina, Reis, Salette, Vale, M Luísa do
Format: Article
Language:English
Subjects:
Amino acids
amphiphiles
Biodegradability
Biodegradation
Chemical compounds
chemical permeation enhancer
Drug delivery
Drugs
Fatty acids
Lipids
Lipophilic
Penetration
Permeability
Review
Skin
Toxicity
transdermal delivery
Transdermal medication
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Summary:Transdermal drug delivery (TDD) presents many advantages compared to other conventional routes of drug administration, yet its full potential has not been achieved. The administration of drugs through the skin is hampered by the natural barrier properties of the skin, which results in poor permeation of most drugs. Several methods have been developed to overcome this limitation. One of the approaches to increase drug permeation and thus to enable TDD for a wider range of drugs consists in the use of chemical permeation enhancers (CPEs), compounds that interact with skin to ultimately increase drug flux. Amino acid derivatives show great potential as permeation enhancers, as they exhibit high biodegradability and low toxicity. Here we present an overview of amino acid derivatives investigated so far as CPEs for the delivery of hydrophilic and lipophilic drugs across the skin, focusing on the structural features which promote their enhancement capacity.
ISSN:2077-0375
2077-0375
DOI:10.3390/membranes11050343