Efficacy of human papillomavirus l1 protein vaccines (cervarix and gardasil) in reducing the risk of cervical intraepithelial neoplasia: A meta-analysis

Human papillomavirus (HPV) can induce cervical intraepithelial neoplasia (CIN). Vaccination against HPV can play an important role in CIN prevention. This study aims to estimate the efficacy of L1 protein vaccines (Cervarix and Gardasil) in CIN 1, 2, 3 risk reduction using meta-analysis. Relevant ar...

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Bibliographic Details
Published in:International journal of preventive medicine 2017-01, Vol.8 (1), p.44-44
Main Authors: Haghshenas, Mohammad, Mousavi, Tahoora, Kheradmand, Motahareh, Afshari, Mahdi, Moosazadeh, Mahmood
Format: Article
Language:English
Subjects:
Aluminum
Cervical cancer
Cervical intraepithelial neoplasia
Cervix dysplasia
Chinese medicine
Clinical trials
efficacy
Health sciences
Human papillomavirus
Immune system
Infections
L1 protein
Medical research
Meta-analysis
Papillomavirus vaccines
Prevention
Proteins
Quality
Quality control
Research centers
Researchers
Review
Risk reduction
Studies
vaccine
Vaccines
Variance analysis
Womens health
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Summary:Human papillomavirus (HPV) can induce cervical intraepithelial neoplasia (CIN). Vaccination against HPV can play an important role in CIN prevention. This study aims to estimate the efficacy of L1 protein vaccines (Cervarix and Gardasil) in CIN 1, 2, 3 risk reduction using meta-analysis. Relevant articles were identified by two independent researchers searching international databanks. After application of inclusion/exclusion criteria and quality assessment, eligible articles were entered into the final meta-analysis. Inverse variance method and fixed effect model were used to combine the results of the primary studies. The heterogeneity between the results was assessed using Cochrane and I2 indices. Of 11,530 evidence identified during the primary search, three papers were found eligible for meta-analysis, including 7213 participants in the intervention groups and 7170 healthy controls. The efficacy (95% confidence interval) of HPV 6, 11, 16, 18 monovalent and quadrivalent vaccines against CIN 1, CIN 2, and CIN 3 were estimated as of 95% (88-98), 97% (85-99), and 95% (78-99), respectively. This study showed that L1 protein vaccines Cervarix and Gardasil are highly protective vaccines playing an effective role in the prevention of HPV 6, 11, 16, 18 which are responsible for CIN 1, CIN 2, and CIN 3.
ISSN:2008-7802
2008-8213
DOI:10.4103/ijpvm.IJPVM_413_16