Polyelectrolyte Membrane Nanocoatings Aimed at Personal Protective and Medical Equipment Surfaces to Reduce Coronavirus Spreading

The study of the surface of membrane coatings constructed with adsorbed coronavirus (COV) was described to test their suitability for the antiviral activity for application in personal protective and medical equipment. The nanocoating based on polyethyleneimine (PEI) or polystyrene sulfonate (PSS) w...

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Bibliographic Details
Published in:Membranes (Basel) 2022-09, Vol.12 (10), p.946
Main Authors: Grzeczkowicz, Anna, Lipko, Agata, Kwiatkowska, Angelika, Strawski, Marcin, Bącal, Paweł, Więckowska, Agnieszka, Granicka, Ludomira H
Format: Article
Language:English
Subjects:
Antiviral activity
Antiviral agents
Atomic force microscopy
Biomedical materials
Cancer
Chloride
Coatings
Comparative analysis
Coronavirus infections
Coronaviruses
COVID-19
Disease transmission
Ethylenediaminetetraacetic acid
Flow cytometry
Gold
Graphene
Lungs
Medical equipment
medical equipment surfaces
Membranes
Nanoparticles
Pandemics
personal protective equipment
Physiological apparatus
polyelectrolyte membranes
Polyelectrolytes
Polyethyleneimine
Polymers
Polystyrene
Polystyrene resins
Protective clothing
Severe acute respiratory syndrome coronavirus 2
Silver
Viruses
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Summary:The study of the surface of membrane coatings constructed with adsorbed coronavirus (COV) was described to test their suitability for the antiviral activity for application in personal protective and medical equipment. The nanocoating based on polyethyleneimine (PEI) or polystyrene sulfonate (PSS) with metallic nanoparticles incorporated was investigated using the AFM technique. Moreover, the functioning of human lung cells in a configuration with the prepared material with the adsorbed coronavirus was studied using microscopic techniques and flow cytometry. The mean values of the percentage share of viable cells compared with the control differed by a maximum of 22%. The results showed that PEI and PSS membrane layer coatings, modified with chosen metallic nanoparticles (AuNPs, AgNPs, CuNPs, FeNPs) that absorb COV, could support lung cells’ function, despite the different distribution patterns of COV on designed surfaces as well as immobilized lung cells. Therefore, the developed membrane nanocoatings can be recommended as material for biomedical applications, e.g., medical equipment surfaces to reduce coronavirus spreading, as they adsorb COV and simultaneously maintain the functioning of the eukaryotic cells.
ISSN:2077-0375
2077-0375
DOI:10.3390/membranes12100946