Multimodality Imaging Evaluation of Coronary IgG4-Related Disease: A "Tumor-Like" Cardiac Lesion

Immunoglobulin G4-related disease (IgG4-RD) is a systemic immune-mediated fibro-inflammatory disorder. Coronary IgG4-RD has been scarcely reported and may present as "tumor-like" lesions. These pseudo-masses may be underdiagnosed mainly due to a vague clinical picture that can vary from co...

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Bibliographic Details
Published in:Diagnostics (Basel) 2022-11, Vol.12 (11), p.2814
Main Authors: Lanzafame, Ludovica R M, Carerj, Maria Ludovica, Rizzo, Giovanna, Minutoli, Fabio, Bucolo, Giuseppe M, Irrera, Natasha, Muscogiuri, Giuseppe, Sironi, Sandro, Blandino, Alfredo, D'Angelo, Tommaso
Format: Article
Language:English
Subjects:
Acute coronary syndromes
Aneurysms
Asymptomatic
autoimmune disease
Biopsy
cardiac-gated imaging techniques
Cardiovascular disease
Case Report
coronary artery disease
Coronary vessels
Diagnosis
Diagnosis, Differential
Diagnostic imaging
Health aspects
IgG4-associated
IgG4-related disease
Immunoglobulin G
Immunologic diseases
Inflammation
Inflammatory diseases
Iodine
Laboratories
Methods
Patients
Remission (Medicine)
Serology
systemic vasculitis
Tomography
Tumors
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Summary:Immunoglobulin G4-related disease (IgG4-RD) is a systemic immune-mediated fibro-inflammatory disorder. Coronary IgG4-RD has been scarcely reported and may present as "tumor-like" lesions. These pseudo-masses may be underdiagnosed mainly due to a vague clinical picture that can vary from complete lack of symptoms to acute coronary syndrome or sudden cardiac death. Early recognition of coronary IgG4-RD is essential to monitor disease activity and prevent life-threatening complications. We report a comprehensive non-invasive imaging evaluation of a patient affected by coronary IgG4-RD, which was diagnosed as an incidental finding during routine pre-laparoscopic cholecystectomy checkup. Non-invasive imaging revealed the presence of a peri-coronary soft-tissue mass that was stable at 12 months follow-up.
ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics12112814