HLA in isolated REM sleep behavior disorder and Lewy body dementia

Synucleinopathies-related disorders such as Lewy body dementia (LBD) and isolated/idiopathic REM sleep behavior disorder (iRBD) have been associated with neuroinflammation. In this study, we examined whether the human leukocyte antigen (HLA) locus plays a role in iRBD and LBD. In iRBD, HLA-DRB1*11:0...

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Published in:Annals of clinical and translational neurology 2023-09, Vol.10 (9), p.1682-1687
Main Authors: Yu, Eric, Krohn, Lynne, Ruskey, Jennifer A, Asayesh, Farnaz, Spiegelman, Dan, Shah, Zalak, Chia, Ruth, Arnulf, Isabelle, Hu, Michele T M, Montplaisir, Jacques Y, Gagnon, Jean-François, Desautels, Alex, Dauvilliers, Yves, Gigli, Gian Luigi, Valente, Mariarosaria, Janes, Francesco, Bernardini, Andrea, Högl, Birgit, Stefani, Ambra, Ibrahim, Abubaker, Heidbreder, Anna, Sonka, Karel, Dusek, Petr, Kemlink, David, Oertel, Wolfgang, Janzen, Annette, Plazzi, Giuseppe, Antelmi, Elena, Figorilli, Michela, Puligheddu, Monica, Mollenhauer, Brit, Trenkwalder, Claudia, Sixel-Döring, Friederike, Cochen De Cock, Valérie, Ferini-Strambi, Luigi, Dijkstra, Femke, Viaene, Mineke, Abril, Beatriz, Boeve, Bradley F, Rouleau, Guy A, Postuma, Ronald B, Scholz, Sonja W, Gan-Or, Ziv
Format: Article
Language:English
Subjects:
Amino acids
Antigens
Behavior disorders
Brief Communication
Brief Communications
Consortia
Dementia
Genomes
Haplotypes
HLA Antigens
HLA-DRB1 Chains
Human health and pathology
Humans
Immune system
Lewy Body Disease
Life Sciences
Parkinson's disease
Quality control
REM sleep
REM Sleep Behavior Disorder
Sleep
Statistical power
Synucleinopathies
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Summary:Synucleinopathies-related disorders such as Lewy body dementia (LBD) and isolated/idiopathic REM sleep behavior disorder (iRBD) have been associated with neuroinflammation. In this study, we examined whether the human leukocyte antigen (HLA) locus plays a role in iRBD and LBD. In iRBD, HLA-DRB1*11:01 was the only allele passing FDR correction (OR = 1.57, 95% CI = 1.27-1.93, p = 2.70e-05). We also discovered associations between iRBD and HLA-DRB1 70D (OR = 1.26, 95%CI = 1.12-1.41, p = 8.76e-05), 70Q (OR = 0.81, 95%CI = 0.72-0.91, p = 3.65e-04) and 71R (OR = 1.21, 95%CI = 1.08-1.35, p = 1.35e-03). Position 71 (p  = 0.00102) and 70 (p  = 0.00125) were associated with iRBD. Our results suggest that the HLA locus may have different roles across synucleinopathies.
ISSN:2328-9503
2328-9503
DOI:10.1002/acn3.51841