Association of Autoantibodies against M2-Muscarinic Acetylcholine Receptor with Atrial Fibrosis in Atrial Fibrillation Patients

Objectives. To investigate the association of serum autoantibodies against M2-muscarinic acetylcholine receptor (anti-M2-R) with atrial fibrosis in long-standing persistent atrial fibrillation (AF) patients. Methods. Twenty-four long-standing persistent AF patients, scheduled to undergo hybrid ablat...

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Bibliographic Details
Published in:Cardiology research and practice 2019-01, Vol.2019 (2019), p.1-10
Main Authors: Zhang, Lin, Liu, Xing-Peng, Jin, Jiawei, Zeng, Lijun, Wu, Xuejiao, Ma, Guiling, Zhang, Jianjun
Format: Article
Language:English
Subjects:
Ablation
Antibodies
Biotechnology
Cardiac arrhythmia
Cardiovascular disease
Collagen
Coronary vessels
Extracellular matrix
Membranes
Proteins
Surgery
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Summary:Objectives. To investigate the association of serum autoantibodies against M2-muscarinic acetylcholine receptor (anti-M2-R) with atrial fibrosis in long-standing persistent atrial fibrillation (AF) patients. Methods. Twenty-four long-standing persistent AF patients, scheduled to undergo hybrid ablation surgery, were enrolled in the study. Twenty-six patients with sinus rhythm, scheduled to undergo coronary artery bypass grafting surgery, were enrolled into the non-AF group. We detected serum anti-M2-R levels. Left atrial appendages were subjected to histological and molecular biological assays. Patients in the AF group received follow-up for two years. Results. The AF group showed significantly higher serum anti-M2-R levels compared to the non-AF group (496.2 ± 232.5 vs. 86.3 ± 25.7 pmol/L, p
ISSN:2090-8016
2090-0597
DOI:10.1155/2019/8271871