Effects of acupuncture at acupoints with lower versus higher pain threshold for knee osteoarthritis: a multicenter randomized controlled trial

The acupoint selections impact the effects of acupuncture, and preliminary evidence showed potential connection between pain threshold (PT) and acupuncture response. This study examined whether acupuncture at acupoints with lower PT versus higher PT would yield different effects in patients with kne...

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Published in:Chinese medicine 2022-06, Vol.17 (1), p.67-67, Article 67
Main Authors: Liu, Jiali, Li, Ying, Li, Ling, Luo, Xiaochao, Li, Ning, Yang, Xuguang, Zhang, Hongxing, Liu, Zhibin, Kang, Deying, Luo, Yanan, Liu, Yanmei, Jia, Yulong, Ren, Yan, Yao, Minghong, Wang, Yuning, Chen, Jin, Maiji, Mewujia, Zou, Kang, Zhao, Ling, Liang, Fanrong, Sun, Xin
Format: Article
Language:English
Subjects:
Acupuncture
Analysis
Arthritis
Chinese medicine
Clinical trials
Hospitals
Knee
Nonsteroidal anti-inflammatory drugs
Osteoarthritis
Pain
Patients
Surgery
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Summary:The acupoint selections impact the effects of acupuncture, and preliminary evidence showed potential connection between pain threshold (PT) and acupuncture response. This study examined whether acupuncture at acupoints with lower PT versus higher PT would yield different effects in patients with knee osteoarthritis (KOA). In this multicenter randomized clinical trial, patients were randomly assigned (1:1:1) to receive acupuncture at acupoints with lower PT (LPT group), acupuncture at acupoints with higher PT (HPT group), and no acupuncture (waiting-list group). PT was measured with electronic von Frey detector. The primary outcome was the change in WOMAC total score from baseline to 16 weeks, and the secondary outcomes were SF-12 score, and active knee range of motion (ROM). Intention-to-treat analysis was conducted with linear mixed-effect model. Among 666 randomized patients, 625 (93.84%) completed the study. From baseline to 16 weeks, patients in the LPT group versus HPT group had similar effects in reducing WOMAC total score (adjusted mean difference (MD) 2.21, 95% confidence interval (CI) -2.51 to 6.92, P = 0.36), while a greater reduction in WOMAC total score was observed in LPT group (-9.77, 95% CI -14.47 to -5.07, P 
ISSN:1749-8546
1749-8546
DOI:10.1186/s13020-022-00626-3