Entrectinib-induced syndrome of inappropriate antidiuretic hormone secretion in a patient with ROS1 -rearranged non-small cell lung cancer

A 75-year-old woman was referred to our hospital because of a productive cough and an abnormal shadow on chest radiography. She was diagnosed as having metastatic lung adenocarcinoma harbouring ROS proto-oncogene 1 ( ). First-line therapy was instituted with entrectinib 600 mg daily, and a gradual d...

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Bibliographic Details
Published in:Respirology case reports 2023-10, Vol.11 (10), p.e01217-n/a
Main Authors: Kato, Chiaki, Sekiya, Muneyuki, Sekiguchi, Ryo, Yamasaki, Akira, Yoshizawa, Takahiro, Isobe, Kazutoshi, Tochigi, Naobumi, Shibuya, Kazutoshi, Kishi, Kazuma
Format: Article
Language:English
Subjects:
Cancer therapies
Case Report
Case Reports
Drug dosages
Entrectinib
Hyponatremia
Kinases
Lung cancer
Metastasis
non‐small cell lung cancer
Osmosis
Radiography
ROS‐1
Sodium
syndrome of inappropriate antidiuretic hormone secretion
Tomography
Tumors
Ultrasonic imaging
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Summary:A 75-year-old woman was referred to our hospital because of a productive cough and an abnormal shadow on chest radiography. She was diagnosed as having metastatic lung adenocarcinoma harbouring ROS proto-oncogene 1 ( ). First-line therapy was instituted with entrectinib 600 mg daily, and a gradual decrease in serum sodium level was noticed on day 6, which deteriorated to Grade 3 hyponatremia on day 12. Despite a partial therapeutic response to entrectinib, she developed fatigue and dizziness, so the drug was withdrawn. The clinical findings and laboratory workup were compatible with a diagnosis of syndrome of inappropriate antidiuretic hormone secretion (SIADH) due to entrectinib. The hyponatremia subsequently improved and entrectinib was resumed at a reduced dose of 400 mg daily, which has been continued to date, with no recurrence of SIADH.
ISSN:2051-3380
2051-3380
DOI:10.1002/rcr2.1217