Insecticidal Activity and Free Radical Scavenging Properties of Isolated Phytoconstituents from the Saudi Plant Nuxia oppositifolia (Hochst.)

Chromatographic purification of the alcoholic extract from the aerial parts of the Saudi plant (Hochst.), Benth., resulted in five isolated phenolic compounds. Two flavones, hispidulin ( ) and jaceosidin ( ), and the phenylethanoid glycosides, verbascoside ( ), isoverbascoside ( ), and conandroside...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2021-02, Vol.26 (4), p.914
Main Authors: Al-Massarani, Shaza M, El-Gamal, Ali A, Al-Rehaily, Adnan J, Al-Sheddi, Ebtesam S, Al-Oqail, Mai M, Farshori, Nida N, Estep, Alden S, Tabanca, Nurhayat, Becnel, James J
Format: Article
Language:English
Subjects:
Acids
Aedes - drug effects
Aedes - growth & development
Aedes aegypti
Animals
Antioxidants
Antioxidants - pharmacology
Ascorbic acid
Binding sites
biopesticides
Chromatography
Cytotoxicity
Evaluation
Flavones
Flavonoids
Free Radical Scavengers - pharmacology
Free radicals
Glycosides
Insecticides - pharmacology
Metabolites
Mortality
mosquito control
Mosquitoes
Nuxia oppositifolia
Pharmacy
Phenolic compounds
Phenols
phenylethanoid
Phytochemicals
Phytochemicals - pharmacology
Plant extracts
Plant Extracts - pharmacology
Saudi Arabia
Scavenging
Secondary metabolites
Tracheophyta - chemistry
triterpenes
Vector-borne diseases
Yellow fever
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Summary:Chromatographic purification of the alcoholic extract from the aerial parts of the Saudi plant (Hochst.), Benth., resulted in five isolated phenolic compounds. Two flavones, hispidulin ( ) and jaceosidin ( ), and the phenylethanoid glycosides, verbascoside ( ), isoverbascoside ( ), and conandroside ( ), were identified and their chemical structures were determined by spectroscopic analyses. The insecticidal activity of compounds and in addition to 11 compounds isolated in a previous research ( - ), was evaluated against the Yellow Fever mosquito, . Four compounds displayed adulticidal activity with LD values of 2-2.3 μg/mosquito. Free radical scavenging properties of the plant extracts and compounds ( - ) were evaluated by measuring the 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonate radical cation (ABTS ) scavenging activity. All compounds exhibited notable activity, compared with the positive control, l-Ascorbic acid. This study suggests that could be a promising source of secondary metabolites, some with lethal adulticidal effect against .
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules26040914