NMR reaction monitoring in flow synthesis

Recent advances in the use of flow chemistry with in-line and on-line analysis by NMR are presented. The use of macro- and microreactors, coupled with standard and custom made NMR probes involving microcoils, incorporated into high resolution and benchtop NMR instruments is reviewed. Some recent sel...

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Bibliographic Details
Published in:Beilstein journal of organic chemistry 2017-02, Vol.13 (1), p.285-300
Main Authors: Gomez, M Victoria, de la Hoz, Antonio
Format: Article
Language:English
Subjects:
Automation
Chemistry
Design
expert systems
flow chemistry
Laboratories
Magnetic fields
microcoil
NMR
NMR probes
Nuclear magnetic resonance
Nuclear reactors
Optimization
Review
Solvents
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Summary:Recent advances in the use of flow chemistry with in-line and on-line analysis by NMR are presented. The use of macro- and microreactors, coupled with standard and custom made NMR probes involving microcoils, incorporated into high resolution and benchtop NMR instruments is reviewed. Some recent selected applications have been collected, including synthetic applications, the determination of the kinetic and thermodynamic parameters and reaction optimization, even in single experiments and on the μL scale. Finally, software that allows automatic reaction monitoring and optimization is discussed.
ISSN:1860-5397
2195-951X
1860-5397
DOI:10.3762/bjoc.13.31