Intestinal toxicity of deoxynivalenol is limited by supplementation with Lactobacillus plantarum JM113 and consequentially altered gut microbiota in broiler chickens

Limited research has focused on the effect of on the intestinal toxicity of deoxynivalenol (DON). The present study was conducted to investigate the role of JM113 in protecting against the intestinal toxicity caused by DON. A total of 144 one-day-old healthy Arbor Acres broilers were randomly distri...

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Bibliographic Details
Published in:Journal of animal science and biotechnology 2018-10, Vol.9 (1), p.74-74, Article 74
Main Authors: Wu, Shengru, Liu, Yanli, Duan, Yongle, Wang, Fangyuan, Guo, Fangshen, Yan, Fang, Yang, Xiaojun, Yang, Xin
Format: Article
Language:English
Subjects:
16S rRNA gene sequencing
Absorption
Abundance
Apoptosis
Bacteria
Broiler chickens
Bursa of Fabricius
Butyric acid
Chickens
Crypts
Deoxynivalenol
Diet
Dietary supplements
Digestive enzymes
Digestive system
Duodenum
Feeds
Gastrointestinal tract
Gene expression
Gut microbiota
Immunoglobulin A
Injury prevention
Interleukin 10
Interleukin 12
Intestinal absorption
Intestinal microflora
Intestine
Jejunum
Lactobacillus
Lactobacillus plantarum
Lactobacillus plantarum JM113
Metabolism
Microbiota
Morphological indexes
Morphology
mRNA sequencing
Nutrient utilization
Pancreas
Performance indices
Plant protection
Poultry
Propionic acid
Relative abundance
Signal transduction
Toxicity
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Summary:Limited research has focused on the effect of on the intestinal toxicity of deoxynivalenol (DON). The present study was conducted to investigate the role of JM113 in protecting against the intestinal toxicity caused by DON. A total of 144 one-day-old healthy Arbor Acres broilers were randomly distributed into 3 treatments, including the CON (basal diet), the DON (extra 10 mg/kg deoxynivalenol), and the DL (extra 1 × 10  CFU/ kg JM113 based on DON group) treatments. The growth performance, organ indexes, intestinal morphology, pancreatic digestive enzymes, intestinal secreted immunoglobulin A (sIgA), jejunal transcriptome, and intestinal microbiota were evaluated. Compared with the CON and DL groups, the DON supplementation altered intestinal morphology, especially in duodenum and jejunum, where villi were shorter and crypts were deeper (  
ISSN:1674-9782
2049-1891
2049-1891
DOI:10.1186/s40104-018-0286-5