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Intestinal toxicity of deoxynivalenol is limited by supplementation with Lactobacillus plantarum JM113 and consequentially altered gut microbiota in broiler chickens
Limited research has focused on the effect of on the intestinal toxicity of deoxynivalenol (DON). The present study was conducted to investigate the role of JM113 in protecting against the intestinal toxicity caused by DON. A total of 144 one-day-old healthy Arbor Acres broilers were randomly distri...
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| Published in: | Journal of animal science and biotechnology 2018-10, Vol.9 (1), p.74-74, Article 74 |
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| creator | Wu, Shengru Liu, Yanli Duan, Yongle Wang, Fangyuan Guo, Fangshen Yan, Fang Yang, Xiaojun Yang, Xin |
| description | Limited research has focused on the effect of
on the intestinal toxicity of deoxynivalenol (DON). The present study was conducted to investigate the role of
JM113 in protecting against the intestinal toxicity caused by DON.
A total of 144 one-day-old healthy Arbor Acres broilers were randomly distributed into 3 treatments, including the CON (basal diet), the DON (extra 10 mg/kg deoxynivalenol), and the DL (extra 1 × 10
CFU/ kg
JM113 based on DON group) treatments. The growth performance, organ indexes, intestinal morphology, pancreatic digestive enzymes, intestinal secreted immunoglobulin A (sIgA), jejunal transcriptome, and intestinal microbiota were evaluated.
Compared with the CON and DL groups, the DON supplementation altered intestinal morphology, especially in duodenum and jejunum, where villi were shorter and crypts were deeper (
|
| doi_str_mv | 10.1186/s40104-018-0286-5 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_07d077e5e57b44ab892310bb31a6dec9</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_07d077e5e57b44ab892310bb31a6dec9</doaj_id><sourcerecordid>2123717640</sourcerecordid><originalsourceid>FETCH-LOGICAL-c594t-125636102c8bc8ff865424e55f025be72e92db2867c59ce08163f6014b71c47f3</originalsourceid><addsrcrecordid>eNpdks1u1DAUhSMEoqPSB2CDLLFhE_B1_JcNEqr4GTSIDawt23FmPDjxYDul80C8J26nVBRvLPme--ne49M0zwG_BpD8TaYYMG0xyBYTyVv2qFkRTPsWZA-PmxVwQdteSHLWXOS8x_VwIjoJT5uzDnedxJytmt_rubhc_KwDKvHaW1-OKI5ocPH6OPsrHdwcA_IZBT_54gZkjigvh0Nwk5uLLj7O6JcvO7TRtkSjrQ9hyegQdK2mZUKfvwB0SM8DsnHO7udS27wO4Yh0KC5V4nYpaPI2ReNj0cjPyKTog0vI7rz94eb8rHky6pDdxd193nz_8P7b5ad28_Xj-vLdprWsp6UFwnjHARMrjZXjKDmjhDrGRkyYcYK4ngymmiWq3josgXcjx0CNAEvF2J036xN3iHqvDslPOh1V1F7dPsS0VToVb4NTWAxYCMccE4ZSbWRPOsDGdKD54GxfWW9PrMNiJjfYunbS4QH0YWX2O7WNV4qDoIyLCnh1B0ixupaLmny2LlRnXVyyIkA6AYJTXKUv_5Pu45Lqn96qCJEMKK8qOKmq1TknN94PA1jdZEqdMqVqptRNphSrPS_-3eK-42-Cuj9U4Mq7</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2122285146</pqid></control><display><type>article</type><title>Intestinal toxicity of deoxynivalenol is limited by supplementation with Lactobacillus plantarum JM113 and consequentially altered gut microbiota in broiler chickens</title><source>PubMed Central (Open Access)</source><source>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</source><creator>Wu, Shengru ; Liu, Yanli ; Duan, Yongle ; Wang, Fangyuan ; Guo, Fangshen ; Yan, Fang ; Yang, Xiaojun ; Yang, Xin</creator><creatorcontrib>Wu, Shengru ; Liu, Yanli ; Duan, Yongle ; Wang, Fangyuan ; Guo, Fangshen ; Yan, Fang ; Yang, Xiaojun ; Yang, Xin</creatorcontrib><description><![CDATA[Limited research has focused on the effect of
on the intestinal toxicity of deoxynivalenol (DON). The present study was conducted to investigate the role of
JM113 in protecting against the intestinal toxicity caused by DON.
A total of 144 one-day-old healthy Arbor Acres broilers were randomly distributed into 3 treatments, including the CON (basal diet), the DON (extra 10 mg/kg deoxynivalenol), and the DL (extra 1 × 10
CFU/ kg
JM113 based on DON group) treatments. The growth performance, organ indexes, intestinal morphology, pancreatic digestive enzymes, intestinal secreted immunoglobulin A (sIgA), jejunal transcriptome, and intestinal microbiota were evaluated.
Compared with the CON and DL groups, the DON supplementation altered intestinal morphology, especially in duodenum and jejunum, where villi were shorter and crypts were deeper (
< 0.05). Meanwhile, the significantly decreased mRNA expression of jejunal claudin-1 and occludin (
< 0.05), ileal
and jejunal
of 21-day-old broilers (
< 0.05), as well as duodenal
and ileal
of 42-day-old broilers were identified in the DON group. Moreover, supplementation with
JM113 could increase duodenal expression of
and
of 21-day-old broilers, ileal sIgA of 42-day-old broilers, and the bursa of Fabricius index of 21-day-old broilers. Further jejunal transcriptome proved that the genes related to the intestinal absorption and metabolism were significantly reduced in the DON group but a significant increase when supplemented with extra
JM113. Furthermore, the bacteria related to nutrient utilization, including the Proteobacteria,
,
< 0.05
,
and
(
< 0.1) were all decreased in the DON group. By contrast, supplementation with
JM113 increased the relative abundance of beneficial bacterium, including the Bacteroidetes,
,
,
, and
(
< 0.05). Specifically, the increased abundance of bacteria in the DL group could be proved by the significantly increased caecal content of propionic acid, n-Butyric acid, and total short-chain fatty acid.
JM113 enhanced the digestion, absorption, and metabolic functions of the gut when challenged with DON by reducing the injury to intestinal barriers and by increasing the abundance of beneficial bacterium.]]></description><identifier>ISSN: 1674-9782</identifier><identifier>ISSN: 2049-1891</identifier><identifier>EISSN: 2049-1891</identifier><identifier>DOI: 10.1186/s40104-018-0286-5</identifier><identifier>PMID: 30338065</identifier><language>eng</language><publisher>England: BioMed Central</publisher><subject>16S rRNA gene sequencing ; Absorption ; Abundance ; Apoptosis ; Bacteria ; Broiler chickens ; Bursa of Fabricius ; Butyric acid ; Chickens ; Crypts ; Deoxynivalenol ; Diet ; Dietary supplements ; Digestive enzymes ; Digestive system ; Duodenum ; Feeds ; Gastrointestinal tract ; Gene expression ; Gut microbiota ; Immunoglobulin A ; Injury prevention ; Interleukin 10 ; Interleukin 12 ; Intestinal absorption ; Intestinal microflora ; Intestine ; Jejunum ; Lactobacillus ; Lactobacillus plantarum ; Lactobacillus plantarum JM113 ; Metabolism ; Microbiota ; Morphological indexes ; Morphology ; mRNA sequencing ; Nutrient utilization ; Pancreas ; Performance indices ; Plant protection ; Poultry ; Propionic acid ; Relative abundance ; Signal transduction ; Toxicity</subject><ispartof>Journal of animal science and biotechnology, 2018-10, Vol.9 (1), p.74-74, Article 74</ispartof><rights>Copyright © 2018. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s). 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c594t-125636102c8bc8ff865424e55f025be72e92db2867c59ce08163f6014b71c47f3</citedby><cites>FETCH-LOGICAL-c594t-125636102c8bc8ff865424e55f025be72e92db2867c59ce08163f6014b71c47f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2122285146/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2122285146?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25752,27923,27924,37011,37012,44589,53790,53792,74897</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30338065$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Shengru</creatorcontrib><creatorcontrib>Liu, Yanli</creatorcontrib><creatorcontrib>Duan, Yongle</creatorcontrib><creatorcontrib>Wang, Fangyuan</creatorcontrib><creatorcontrib>Guo, Fangshen</creatorcontrib><creatorcontrib>Yan, Fang</creatorcontrib><creatorcontrib>Yang, Xiaojun</creatorcontrib><creatorcontrib>Yang, Xin</creatorcontrib><title>Intestinal toxicity of deoxynivalenol is limited by supplementation with Lactobacillus plantarum JM113 and consequentially altered gut microbiota in broiler chickens</title><title>Journal of animal science and biotechnology</title><addtitle>J Anim Sci Biotechnol</addtitle><description><![CDATA[Limited research has focused on the effect of
on the intestinal toxicity of deoxynivalenol (DON). The present study was conducted to investigate the role of
JM113 in protecting against the intestinal toxicity caused by DON.
A total of 144 one-day-old healthy Arbor Acres broilers were randomly distributed into 3 treatments, including the CON (basal diet), the DON (extra 10 mg/kg deoxynivalenol), and the DL (extra 1 × 10
CFU/ kg
JM113 based on DON group) treatments. The growth performance, organ indexes, intestinal morphology, pancreatic digestive enzymes, intestinal secreted immunoglobulin A (sIgA), jejunal transcriptome, and intestinal microbiota were evaluated.
Compared with the CON and DL groups, the DON supplementation altered intestinal morphology, especially in duodenum and jejunum, where villi were shorter and crypts were deeper (
< 0.05). Meanwhile, the significantly decreased mRNA expression of jejunal claudin-1 and occludin (
< 0.05), ileal
and jejunal
of 21-day-old broilers (
< 0.05), as well as duodenal
and ileal
of 42-day-old broilers were identified in the DON group. Moreover, supplementation with
JM113 could increase duodenal expression of
and
of 21-day-old broilers, ileal sIgA of 42-day-old broilers, and the bursa of Fabricius index of 21-day-old broilers. Further jejunal transcriptome proved that the genes related to the intestinal absorption and metabolism were significantly reduced in the DON group but a significant increase when supplemented with extra
JM113. Furthermore, the bacteria related to nutrient utilization, including the Proteobacteria,
,
< 0.05
,
and
(
< 0.1) were all decreased in the DON group. By contrast, supplementation with
JM113 increased the relative abundance of beneficial bacterium, including the Bacteroidetes,
,
,
, and
(
< 0.05). Specifically, the increased abundance of bacteria in the DL group could be proved by the significantly increased caecal content of propionic acid, n-Butyric acid, and total short-chain fatty acid.
JM113 enhanced the digestion, absorption, and metabolic functions of the gut when challenged with DON by reducing the injury to intestinal barriers and by increasing the abundance of beneficial bacterium.]]></description><subject>16S rRNA gene sequencing</subject><subject>Absorption</subject><subject>Abundance</subject><subject>Apoptosis</subject><subject>Bacteria</subject><subject>Broiler chickens</subject><subject>Bursa of Fabricius</subject><subject>Butyric acid</subject><subject>Chickens</subject><subject>Crypts</subject><subject>Deoxynivalenol</subject><subject>Diet</subject><subject>Dietary supplements</subject><subject>Digestive enzymes</subject><subject>Digestive system</subject><subject>Duodenum</subject><subject>Feeds</subject><subject>Gastrointestinal tract</subject><subject>Gene expression</subject><subject>Gut microbiota</subject><subject>Immunoglobulin A</subject><subject>Injury prevention</subject><subject>Interleukin 10</subject><subject>Interleukin 12</subject><subject>Intestinal absorption</subject><subject>Intestinal microflora</subject><subject>Intestine</subject><subject>Jejunum</subject><subject>Lactobacillus</subject><subject>Lactobacillus plantarum</subject><subject>Lactobacillus plantarum JM113</subject><subject>Metabolism</subject><subject>Microbiota</subject><subject>Morphological indexes</subject><subject>Morphology</subject><subject>mRNA sequencing</subject><subject>Nutrient utilization</subject><subject>Pancreas</subject><subject>Performance indices</subject><subject>Plant protection</subject><subject>Poultry</subject><subject>Propionic acid</subject><subject>Relative abundance</subject><subject>Signal transduction</subject><subject>Toxicity</subject><issn>1674-9782</issn><issn>2049-1891</issn><issn>2049-1891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNpdks1u1DAUhSMEoqPSB2CDLLFhE_B1_JcNEqr4GTSIDawt23FmPDjxYDul80C8J26nVBRvLPme--ne49M0zwG_BpD8TaYYMG0xyBYTyVv2qFkRTPsWZA-PmxVwQdteSHLWXOS8x_VwIjoJT5uzDnedxJytmt_rubhc_KwDKvHaW1-OKI5ocPH6OPsrHdwcA_IZBT_54gZkjigvh0Nwk5uLLj7O6JcvO7TRtkSjrQ9hyegQdK2mZUKfvwB0SM8DsnHO7udS27wO4Yh0KC5V4nYpaPI2ReNj0cjPyKTog0vI7rz94eb8rHky6pDdxd193nz_8P7b5ad28_Xj-vLdprWsp6UFwnjHARMrjZXjKDmjhDrGRkyYcYK4ngymmiWq3josgXcjx0CNAEvF2J036xN3iHqvDslPOh1V1F7dPsS0VToVb4NTWAxYCMccE4ZSbWRPOsDGdKD54GxfWW9PrMNiJjfYunbS4QH0YWX2O7WNV4qDoIyLCnh1B0ixupaLmny2LlRnXVyyIkA6AYJTXKUv_5Pu45Lqn96qCJEMKK8qOKmq1TknN94PA1jdZEqdMqVqptRNphSrPS_-3eK-42-Cuj9U4Mq7</recordid><startdate>20181008</startdate><enddate>20181008</enddate><creator>Wu, 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gut microbiota in broiler chickens</title><author>Wu, Shengru ; Liu, Yanli ; Duan, Yongle ; Wang, Fangyuan ; Guo, Fangshen ; Yan, Fang ; Yang, Xiaojun ; Yang, Xin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c594t-125636102c8bc8ff865424e55f025be72e92db2867c59ce08163f6014b71c47f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>16S rRNA gene sequencing</topic><topic>Absorption</topic><topic>Abundance</topic><topic>Apoptosis</topic><topic>Bacteria</topic><topic>Broiler chickens</topic><topic>Bursa of Fabricius</topic><topic>Butyric acid</topic><topic>Chickens</topic><topic>Crypts</topic><topic>Deoxynivalenol</topic><topic>Diet</topic><topic>Dietary supplements</topic><topic>Digestive enzymes</topic><topic>Digestive system</topic><topic>Duodenum</topic><topic>Feeds</topic><topic>Gastrointestinal tract</topic><topic>Gene expression</topic><topic>Gut microbiota</topic><topic>Immunoglobulin A</topic><topic>Injury prevention</topic><topic>Interleukin 10</topic><topic>Interleukin 12</topic><topic>Intestinal absorption</topic><topic>Intestinal microflora</topic><topic>Intestine</topic><topic>Jejunum</topic><topic>Lactobacillus</topic><topic>Lactobacillus plantarum</topic><topic>Lactobacillus plantarum JM113</topic><topic>Metabolism</topic><topic>Microbiota</topic><topic>Morphological indexes</topic><topic>Morphology</topic><topic>mRNA sequencing</topic><topic>Nutrient utilization</topic><topic>Pancreas</topic><topic>Performance indices</topic><topic>Plant protection</topic><topic>Poultry</topic><topic>Propionic acid</topic><topic>Relative abundance</topic><topic>Signal transduction</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Shengru</creatorcontrib><creatorcontrib>Liu, Yanli</creatorcontrib><creatorcontrib>Duan, Yongle</creatorcontrib><creatorcontrib>Wang, Fangyuan</creatorcontrib><creatorcontrib>Guo, Fangshen</creatorcontrib><creatorcontrib>Yan, Fang</creatorcontrib><creatorcontrib>Yang, Xiaojun</creatorcontrib><creatorcontrib>Yang, Xin</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Agricultural Science Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>Advanced Technologies & Aerospace Database (1962 - current)</collection><collection>Agricultural & Environmental Science 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(PQ_SDU_P3)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals (Open Access)</collection><jtitle>Journal of animal science and biotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Shengru</au><au>Liu, Yanli</au><au>Duan, Yongle</au><au>Wang, Fangyuan</au><au>Guo, Fangshen</au><au>Yan, Fang</au><au>Yang, Xiaojun</au><au>Yang, Xin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intestinal toxicity of deoxynivalenol is limited by supplementation with Lactobacillus plantarum JM113 and consequentially altered gut microbiota in broiler chickens</atitle><jtitle>Journal of animal science and biotechnology</jtitle><addtitle>J Anim Sci Biotechnol</addtitle><date>2018-10-08</date><risdate>2018</risdate><volume>9</volume><issue>1</issue><spage>74</spage><epage>74</epage><pages>74-74</pages><artnum>74</artnum><issn>1674-9782</issn><issn>2049-1891</issn><eissn>2049-1891</eissn><abstract><![CDATA[Limited research has focused on the effect of
on the intestinal toxicity of deoxynivalenol (DON). The present study was conducted to investigate the role of
JM113 in protecting against the intestinal toxicity caused by DON.
A total of 144 one-day-old healthy Arbor Acres broilers were randomly distributed into 3 treatments, including the CON (basal diet), the DON (extra 10 mg/kg deoxynivalenol), and the DL (extra 1 × 10
CFU/ kg
JM113 based on DON group) treatments. The growth performance, organ indexes, intestinal morphology, pancreatic digestive enzymes, intestinal secreted immunoglobulin A (sIgA), jejunal transcriptome, and intestinal microbiota were evaluated.
Compared with the CON and DL groups, the DON supplementation altered intestinal morphology, especially in duodenum and jejunum, where villi were shorter and crypts were deeper (
< 0.05). Meanwhile, the significantly decreased mRNA expression of jejunal claudin-1 and occludin (
< 0.05), ileal
and jejunal
of 21-day-old broilers (
< 0.05), as well as duodenal
and ileal
of 42-day-old broilers were identified in the DON group. Moreover, supplementation with
JM113 could increase duodenal expression of
and
of 21-day-old broilers, ileal sIgA of 42-day-old broilers, and the bursa of Fabricius index of 21-day-old broilers. Further jejunal transcriptome proved that the genes related to the intestinal absorption and metabolism were significantly reduced in the DON group but a significant increase when supplemented with extra
JM113. Furthermore, the bacteria related to nutrient utilization, including the Proteobacteria,
,
< 0.05
,
and
(
< 0.1) were all decreased in the DON group. By contrast, supplementation with
JM113 increased the relative abundance of beneficial bacterium, including the Bacteroidetes,
,
,
, and
(
< 0.05). Specifically, the increased abundance of bacteria in the DL group could be proved by the significantly increased caecal content of propionic acid, n-Butyric acid, and total short-chain fatty acid.
JM113 enhanced the digestion, absorption, and metabolic functions of the gut when challenged with DON by reducing the injury to intestinal barriers and by increasing the abundance of beneficial bacterium.]]></abstract><cop>England</cop><pub>BioMed Central</pub><pmid>30338065</pmid><doi>10.1186/s40104-018-0286-5</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of animal science and biotechnology, 2018-10, Vol.9 (1), p.74-74, Article 74 |
| issn | 1674-9782 2049-1891 2049-1891 |
| language | eng |
| recordid | cdi_doaj_primary_oai_doaj_org_article_07d077e5e57b44ab892310bb31a6dec9 |
| source | PubMed Central (Open Access); Publicly Available Content Database (Proquest) (PQ_SDU_P3) |
| subjects | 16S rRNA gene sequencing Absorption Abundance Apoptosis Bacteria Broiler chickens Bursa of Fabricius Butyric acid Chickens Crypts Deoxynivalenol Diet Dietary supplements Digestive enzymes Digestive system Duodenum Feeds Gastrointestinal tract Gene expression Gut microbiota Immunoglobulin A Injury prevention Interleukin 10 Interleukin 12 Intestinal absorption Intestinal microflora Intestine Jejunum Lactobacillus Lactobacillus plantarum Lactobacillus plantarum JM113 Metabolism Microbiota Morphological indexes Morphology mRNA sequencing Nutrient utilization Pancreas Performance indices Plant protection Poultry Propionic acid Relative abundance Signal transduction Toxicity |
| title | Intestinal toxicity of deoxynivalenol is limited by supplementation with Lactobacillus plantarum JM113 and consequentially altered gut microbiota in broiler chickens |
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